Evidence of significant hearing loss during the early days of use of cisplatin as a
chemotherapeutic agent in cancer patients has stimulated research into the causes and …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a vital transcription factor and its induction
is of significant importance for protecting against oxidative damage. Increased levels of …

Cancer cells consume large quantities of nutrients and maintain high levels of anabolism.
Recent studies revealed that various oncogenic pathways are involved in modulation of …

Cap'n'collar (Cnc) transcription factors are conserved in metazoans and have important
developmental and homeostatic functions. The vertebrate Nrf1, Nrf2, and Nrf3; the …

The NRF2/KEAP1 pathway represents one of the most important cell defense mechanisms
against exogenous or endogenous stressors. Indeed, by increasing the expression of …

Background Nuclear factor erythroid-2 related factor 2 (NRF2) is a redox-sensitive
transcription factor that positively regulates the expression of genes encoding antioxidants …

Cisplatin is a widely used chemotherapeutic agent to treat malignant disease. Unfortunately,
ototoxicity occurs in a large percentage of patients treated with higher dose regimens. In …

Cisplatin is a chemotherapeutic agent that is widely used to treat a variety of malignant
tumors. Serious dose-limiting side effects like ototoxicity, nephrotoxicity and neurotoxicity …

Cisplatin is a highly effective antitumor drug generally used in the treatment of solid
malignant tumors. However, cisplatin causes severe side effects such as bone marrow …

It has been well documented in in vitro studies that ambient airborne particulate matter (PM)
with an aerodynamic diameter less than 2.5 μm (PM 2.5) is capable of inducing oxidative …