DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genome integrity and
cell viability. Typically, cells repair DSBs by either nonhomologous end joining (NHEJ) or …

In the cell nucleus, DNA damage signaling and repair machineries operate on a chromatin
substrate, the integrity of which is critical for cell function and viability. Here, we review …

Homologous recombination repairs DNA double-strand breaks (DSB) using an intact dsDNA
molecule as a template. It entails a homology search step, carried out along a conserved …

The substrate for the repair of DNA damage in living cells is not DNA but chromatin.
Chromatin bears a range of modifications, which in turn bind ligands that compact or open …

The cell nucleus can be thought of as a complex, dynamic, living material, which functions to
organize and protect the genome and coordinate gene expression. These functions are …

Eukaryotic cells package their genomes around histone octamers. In response to DNA
damage, checkpoint activation in yeast induces core histone degradation resulting in 20 …

Loss of cytosolic actin filaments upon TORC2 inhibition triggers chromosome fragmentation
in yeast, which results from altered base excision repair of Zeocin-induced lesions. To find …

Homology search is a central step of DNA double-strand break (DSB) repair by homologous
recombination (HR). How it operates in cells remains elusive. We developed a Hi-C-based …

Two related post‐translational modifications, the covalent linkage of Ubiquitin and the Small
Ubiquitin‐related MOdifier (SUMO) to lysine residues, play key roles in the regulation of both …

Eukaryotic organisms adapt to environmental fluctuations by altering their epigenomic
landscapes and transcriptional programs. Nucleosomal histones carry vital epigenetic …