Life depends on cell proliferation and the accurate segregation of chromosomes, which are
mediated by the microtubule (MT)-based mitotic spindle and∼ 200 essential MT-associated …

The mitotic spindle is the macromolecular machine that segregates chromosomes to two
daughter cells during mitosis. The major structural elements of the spindle are microtubule …

Despite many decades of study, mitotic chromosome structure and composition remain
poorly characterized. Here, we have integrated quantitative proteomics with bioinformatic …

Our understanding of the structure and function of mitotic chromosomes has come a long
way since these iconic objects were first recognized more than 140 years ago, though many …

The assembly of mitotic chromosomes, each composed of a pair of rod-shaped chromatids,
is an essential prerequisite for accurate transmission of the genome during cell division. It …

Nuclear genomes of human, animals, and plants are organized into subunits called
chromosomes. When isolated into aqueous suspension, mitotic chromosomes can be …

A complex structure, designated the chromosome periphery, surrounds each chromosome
during mitosis. Although several proteins have been shown to localize to the chromosome …

Mitotic chromosomes respond elastically to forces in the nanonewton range, a property
important to transduction of stresses used as mechanical regulatory signals during cell …

Cohesion is essential for the identification of sister chromatids and for the biorientation of
chromosomes until their segregation. Here, we have demonstrated that an RNA-binding …

The chromosome periphery (CP) is a complex network that covers the outer surface of
chromosomes. It acts as a carrier of nucleolar components, helps maintain chromosome …