Rapid and efficient generation of myelinating human oligodendrocytes in organoids

MR Shaker, G Pietrogrande, S Martin… - Frontiers in cellular …, 2021 - frontiersin.org
Human stem cell derived brain organoids are increasingly gaining attention as an ideal
model system for investigating neurological diseases, particularly those that involve …

The ventricular-subventricular, subgranular and subcallosal zones: three niches of neural stem cells in the postnatal brain

V Lopez-Virgen, O Gonzalez-Morales… - Experimental Brain …, 2023 - Springer
In the postnatal brain, three regions show high mitotic activity. These brain areas are
neurogenic niches, and each niche harbors a microenvironment favorable for the …

Klotho inhibits neuronal senescence in human brain organoids

MR Shaker, J Aguado, HK Chaggar… - npj Aging and …, 2021 - nature.com
Aging is a major risk factor for many neurodegenerative diseases. Klotho (KL) is a
glycosylated transmembrane protein that is expressed in the choroid plexus and neurons of …

Gender-specific effects of transthyretin on neural stem cell fate in the subventricular zone of the adult mouse

P Vancamp, JD Gothié, C Luongo, A Sébillot… - Scientific reports, 2019 - nature.com
Choroid plexus epithelial cells produce and secrete transthyretin (TTR). TTR binds and
distributes thyroid hormone (TH) to brain cells via the cerebrospinal fluid. The adult murine …

[HTML][HTML] Transcriptional signature of valproic acid-induced neural tube defects in human spinal cord organoids

JH Lee, MR Shaker, SH Park… - International Journal of …, 2023 - synapse.koreamed.org
In vertebrates, the entire central nervous system is derived from the neural tube, which is
formed through a conserved early developmental morphogenetic process called …

Neural epidermal growth factor-like like protein 2 is expressed in human oligodendroglial cell types

MR Shaker, A Kahtan, R Prasad, JH Lee… - Frontiers in cell and …, 2022 - frontiersin.org
Neural epidermal growth factor-like like 2 (NELL2) is a cytoplasmic and secreted
glycosylated protein with six epidermal growth factor-like domains. In animal models, NELL2 …

[HTML][HTML] Spatiotemporal contribution of neuromesodermal progenitor-derived neural cells in the elongation of developing mouse spinal cord

MR Shaker, JH Lee, KH Kim, S Ban, VJ Kim, JY Kim… - Life Sciences, 2021 - Elsevier
Aims During vertebrate development, the posterior end of the embryo progressively
elongates in a head-to-tail direction to form the body plan. Recent lineage tracing …

[PDF][PDF] СТАРЕНИЕ СОМАТИЧЕСКИХ СТВОЛОВЫХ КЛЕТОК (ОБЗОР)

БА УМБАЕВ, ЮИ САФАРОВА - scholar.archive.org
Cоматические стволовые клетки представляют собой редкие гетерогенные популяции
недифференцированных клеток, которые обнаруживаются в организме на протяжении …

Methods for generating neural progenitor cells with a spinal cord identity

MG Fehlings, M Khazaei, CS Ahuja - US Patent App. 18/044,288, 2024 - Google Patents
XCGMILZGRGEWHL-UHFFFAOYSA-N CCC (C) C (C (= O) NC (CCCCN) C (= O) NC (C (C)
CC) C (= O) NC (CC1= CNC2= CC= CC= C21) C (= O) NC (CC3= CC= CC= C3) C (= O) NC …

[图书][B] The functions of SIRT7 in the maintenance of neural stem cells and the regulation of the somatotroph axis

R Ohkubo - 2019 - search.proquest.com
SIRT7 is a histone deacetylase that represses the expression of ribosomal proteins and
mitochondrial ribosomal proteins to regulate the unfolded protein responses in the ER (UPR …