Abstract 'Reactive oxygen species'(ROS) is an umbrella term for an array of derivatives of
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …

Background Ageing is the inevitable time-dependent decline in physiological organ function
that eventually leads to death. Age is a major risk factor for many of the most common …

Healthy aging and longevity in humans are modulated by a lucky combination of genetic
and non-genetic factors. Family studies demonstrated that about 25% of the variation in …

People exposed to chronic stress age rapidly. The telomeres in their cells of all types
shorten faster. Inflammation is another important feature of stress that, along with aging …

Research on longevity and healthy aging promises to increase our lifespan and decrease
the burden of degenerative diseases with important social and economic effects. Many …

Highlights What are the main findings? Hypothesis: Redox, bioenergetic and temperature
regulation is critical in maintaining cellular circadian rhythms; wakefulness is mainly …

An ever-increasing number of studies highlight the role of uncoupling protein 2 (UCP2) in a
broad range of physiological and pathological processes. The knowledge of the molecular …

The mouse has become the favorite mammalian model. Among the many reasons for this
privileged position of mice is their genetic proximity to humans, the possibilities of …

Approximately one-quarter of the variation in lifespan in developed countries can be
attributed to genetic factors. However, even large population based studies investigating …

The accumulation of oxidative damage to DNA and other biomolecules plays an important
role in the etiology of aging and age-related diseases such as type 2 diabetes mellitus …