Regulation of ion channels by the serum‐and glucocorticoid‐inducible kinase SGK1

F Lang, E Shumilina - The FASEB Journal, 2013 - Wiley Online Library
The ubiquitously expressed serum‐and glucocorticoid‐inducible kinase‐1 (SGK1) is
genomically regulated by cell stress (including cell shrinkage) and several hormones …

Significance of SGK1 in the regulation of neuronal function

F Lang, N Strutz‐Seebohm, G Seebohm… - The Journal of …, 2010 - Wiley Online Library
The present brief review highlights the putative role of the serum‐and glucocorticoid‐
inducible‐kinase‐1 (SGK1) in the regulation of neuronal function. SGK1 is genomically …

EMD638683, a novel SGK inhibitor with antihypertensive potency

TF Ackermann, KM Boini, N Beier, W Scholz… - Cellular Physiology and …, 2011 - karger.com
The serum-and glucocorticoid-inducible kinase 1 (SGK1) is transcriptionally upregulated by
mineralocorticoids and activated by insulin. The kinase enhances renal tubular Na+ …

Colorectal carcinoma cells—regulation of survival and growth by SGK1

F Lang, N Perrotti, C Stournaras - … journal of biochemistry & cell biology, 2010 - Elsevier
Colorectal carcinoma is among the most common malignancies. The tumour cells may arise
from mutations in genes encoding proteins involved in the regulation of cell survival and …

[HTML][HTML] Stimulation of Ca2+-channel Orai1/STIM1 by serum-and glucocorticoid-inducible kinase 1 (SGK1)

A Eylenstein, EM Gehring, N Heise… - The FASEB …, 2011 - ncbi.nlm.nih.gov
Ca 2+ signaling includes store-operated Ca 2+ entry (SOCE) following depletion of
endoplasmic reticulum (ER) Ca 2+ stores. On store depletion, the ER Ca 2+ sensor STIM1 …

AMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new-born and premature death

J Moral-Sanz, SA Lewis, S MacMillan, M Meloni… - Nature …, 2022 - nature.com
AMPK has been reported to facilitate hypoxic pulmonary vasoconstriction but, paradoxically,
its deficiency precipitates pulmonary hypertension. Here we show that AMPK-α1/α2 …

Downregulation of Mouse Intestinal Na+-coupled Glucose Transporter SGLT1 by Gum Arabic (Acacia Senegal)

O Nasir, F Artunc, K Wang, R Rexhepaj… - Cellular Physiology and …, 2010 - karger.com
Intestinal Na+-coupled glucose transporter SGLT1 determines the rate of glucose transport,
which in turn influences glucose-induced insulin release and development of obesity. The …

The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19

C Böhmer, M Sopjani, F Klaus, R Lindner… - Cellular Physiology and …, 2006 - karger.com
The neutral amino acid transporter SLC6A19 (B⁰AT1) plays a decisive role in transport of
neutral amino acids in the kidney and intestine. Recently, mutations in SLC6A19 were …

Smarter neuronal signaling complexes from existing components: how regulatory modifications were acquired during animal evolution: evolution of palmitoylation …

GM Thomas, T Hayashi - Bioessays, 2013 - Wiley Online Library
Neurons of organisms with complex and flexible behavior, especially humans, must
precisely control protein localization and activity to support higher brain functions such as …

Serum‐and glucocorticoid‐dependent kinase‐1‐induced cell migration is dependent on vinculin and regulated by the membrane androgen receptor

EM Schmidt, S Gu, V Anagnostopoulou… - The FEBS …, 2012 - Wiley Online Library
The serum‐and glucocorticoid‐dependent kinases 1–3 (SGK1–3) are downstream effectors
of phosphatidylinositol 3‐kinases, implicated in various cell responses including colon …