Metal-free multicomponent syntheses of pyridines

C Allais, JM Grassot, J Rodriguez… - Chemical …, 2014 - ACS Publications
They react according to a succession of mono-or bimolecular processes to form at the end
one product that incorporates important portions and functionalities of the starting materials …

Multicomponent reaction design in the quest for molecular complexity and diversity

E Ruijter, R Scheffelaar… - Angewandte Chemie …, 2011 - Wiley Online Library
Multicomponent reactions have become increasingly popular as tools for the rapid
generation of small‐molecule libraries. However, to ensure sufficient molecular diversity and …

Recent developments in asymmetric multicomponent reactions

C de Graaff, E Ruijter, RVA Orru - Chemical Society Reviews, 2012 - pubs.rsc.org
Multicomponent reactions (MCRs) receive increasing attention because they address both
diversity and complexity in organic synthesis. Thus, in principle diverse sets of relatively …

Cyclization Cascades via N-Amidyl Radicals toward Highly Functionalized Heterocyclic Scaffolds

N Fuentes, W Kong… - Journal of the …, 2015 - ACS Publications
The addition of a variety of radicals to the double bond of N-(arylsulfonyl) acrylamides can
trigger cyclization/aryl migration/desulfonylation cascades via amidyl radical intermediates …

Electrochemical Oxo‐Fluorosulfonylation of Alkynes under Air: Facile Access to β‐Keto Sulfonyl Fluorides

D Chen, X Nie, Q Feng, Y Zhang… - Angewandte Chemie …, 2021 - Wiley Online Library
Radical fluorosulfonylation is emerging as an appealing approach for the synthesis of
sulfonyl fluorides, which have widespread applications in many fields, in particular in the …

Organofluorine chemistry: Promising growth areas and challenges

LV Politanskaya, GA Selivanova… - Russian Chemical …, 2019 - iopscience.iop.org
Currently, the chemistry of organofluorine compounds is a leading and rapidly developing
area of organic chemistry. Fluorine present in a molecule largely determines its specific …

Recent developments in asymmetric organocatalytic domino reactions

H Pellissier - Advanced Synthesis & Catalysis, 2012 - Wiley Online Library
Since about the year 2000, the research area of asymmetric organocatalysis has grown
rapidly to become one of the most fascinating and current fields in organic chemistry. In the …

Recent approaches for C–C bond formation via direct dehydrative coupling strategies

R Kumar, EV Van der Eycken - Chemical Society Reviews, 2013 - pubs.rsc.org
In recent years, reaction of inexpensive and abundantly available alcohols (C–OH) with
unactivated nucleophilic coupling partners (C–H), leading to the construction of the C–C …

Recent advances in new multicomponent synthesis of structurally diversified 1, 4-dihydropyridines

JP Wan, Y Liu - RSC advances, 2012 - pubs.rsc.org
1, 4-Dihydropyridines (DHPs) are one of the most important classes of heterocyclic
compounds as privileged pharmacophores. They are therefore attractive synthetic targets of …

Enantioselective organocatalyzed transformations of β-ketoesters

T Govender, PI Arvidsson, GEM Maguire… - Chemical …, 2016 - ACS Publications
The β-ketoester structural motif continues to intrigue chemists with its electrophilic and
nucleophilic sites. Proven to be a valuable tool within organic synthesis, natural product, and …