MAPK-mediated YAP activation controls mechanical-tension-induced pulmonary alveolar regeneration

Z Liu, H Wu, K Jiang, Y Wang, W Zhang, Q Chu, J Li… - Cell reports, 2016 - cell.com
The pulmonary alveolar epithelium undergoes extensive regeneration in response to lung
injuries, including lung resection. In recent years, our understanding of cell lineage …

Stiffer matrix accelerates migration of hepatocellular carcinoma cells through enhanced aerobic glycolysis via the MAPK-YAP signaling

QP Liu, Q Luo, B Deng, Y Ju, GB Song - Cancers, 2020 - mdpi.com
Increased extracellular matrix (ECM) stiffness and metabolic reprogramming of cancer cells
are two fundamental mediators of tumor progression, including hepatocellular carcinoma …

Procyanidin A2, a polyphenolic compound, exerts anti-inflammatory and anti-oxidative activity in lipopolysaccharide-stimulated RAW264. 7 cells

QQ Wang, H Gao, R Yuan, S Han, XX Li, M Tang… - PLoS …, 2020 - journals.plos.org
Procyandin A2 (PCA2) is a polyphenolic compound which is isolated from grape seeds. It
has been reported that PCA2 exhibits antioxidative and anti-inflammatory effects, but its …

The role and activation mechanism of TAZ in hierarchical microgroove/nanopore topography-mediated regulation of stem cell differentiation

P Hu, Q Gao, H Zheng, Y Tian, G Zheng… - International Journal …, 2021 - Taylor & Francis
Purpose To investigate the role and activation mechanism of TAZ in periodontal ligament
stem cells (PDLSCs) perceiving hierarchical microgroove/nanopore topography. Materials …

The underestimated role of mechanical stimuli in brain diseases and the relate d in vitro models

T Guo, P Ren, S Hao, B Wang - Current Pharmaceutical …, 2017 - ingentaconnect.com
Background: Besides the well-documented biochemical and electrophysiological effects, the
mechanical stimuli also have prominent roles in the initiation and development of brain …

Melanoma expressed-CD70 is regulated by RhoA and MAPK pathways without affecting vemurafenib treatment activity

C Pich, I Teiti, G Sarrabayrouse, F Gallardo, R Gence… - PLoS …, 2016 - journals.plos.org
CD70 is a costimulatory molecule member of the Tumor Necrosis Factor family that is
expressed on activated immune cells. Its ectopic expression has been described in several …

Evaluation of the genetic response of U937 and Jurkat cells to 10-nanosecond electrical pulses (nsEP)

CC Roth, RD Glickman, GP Tolstykh, LE Estlack… - PloS one, 2016 - journals.plos.org
Nanosecond electrical pulse (nsEP) exposure activates signaling pathways, produces
oxidative stress, stimulates hormone secretion, causes cell swelling and induces apoptotic …

Dissection of the regulatory elements of the complex expression pattern of puckered, a dual-specificity JNK phosphatase

K Karkali, E Martin-Blanco - International Journal of Molecular Sciences, 2021 - mdpi.com
For developmental processes, we know most of the gene networks controlling specific cell
responses. We still have to determine how these networks cooperate and how signals …

Role of mechanotransduction mediated by YAP/TAZ in the treatment of neurogenic erectile dysfunction with low‐intensity pulsed ultrasound

Y Liu, X Pan, X Zhang, J Sun, Y Mao, Y Yang… - Andrology, 2023 - Wiley Online Library
Background Erectile dysfunction (ED) and weakness of the penis are processes related to
hemodynamic alteration. Low‐intensity pulsed ultrasound (LIPUS), as a new mechanical …