Microfluidic technology is creating powerful tools for cell biologists to control the complete
cellular microenvironment, leading to new questions and new discoveries. We review here …

Culturing cells at microscales allows control over microenvironmental cues, such as cell–cell
and cell–matrix interactions; the potential to scale experiments; the use of small culture …

Liver chips have been developed to recapitulate in vivo physiological conditions to enhance
hepatocyte functions for assessing acute responses to drugs. To develop liver chips that can …

Microscale techniques have been applied to biological assays for nearly two decades, but
haven't been widely integrated as common tools in biological laboratories. The significant …

Microfluidic devices for cell culture based assays provide new types of engineered
microenvironments and new methods for controlling and quantifying cellular responses to …

Oxygen is essential in the energy metabolism of cells, as well as being an important
regulatory parameter influencing cell differentiation and function. Interest in precise oxygen …

A microfluidic chip for generation of gradients of dissolved oxygen was designed, fabricated
and tested. The novel way of active oxygen depletion through a gas permeable membrane …

There is a growing need for efficient mesenchymal stem cell (MSC) production processes for
a wide spectrum of clinical conditions ranging from the treatment of life‐threatening graft …

The heterogeneity of cellular microenvironments in tumors severely limits the efficacy of
most cancer therapies. We have designed a microfluidic device that mimics the …

This paper describes a new technique for the control of spheroid diameter in liver-derived
cell lines using microfabricated chips that were prepared by combining microfabrication with …