Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …

Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as
aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis …

Cancer cells must rewire cellular metabolism to satisfy the demands of unbridled growth and
proliferation. As such, most human cancers differ from normal counterpart tissues by a …

Cell behaviour is strongly influenced by physical, mechanical contacts between cells and
their extracellular matrix. We review how the transcriptional regulators YAP and TAZ …

Hippo signaling is an evolutionarily conserved network that has a central role in regulating
cell proliferation and cell fate to control organ growth and regeneration. It promotes …

One of the most striking adaptations to exercise is the skeletal muscle hypertrophy that
occurs in response to resistance exercise. A large body of work shows that a mammalian …

Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ)
are two homologous transcriptional coactivators that promote cell proliferation, stem cell …

Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

Stiffness in the tissue microenvironment changes in most diseases and immunological
conditions, but its direct influence on the immune system is poorly understood. Here, we …

Recent evidence from cancer research indicates that lactate exerts a suppressive effect on
innate immune responses in cancer. This study investigated the mechanisms by which …