Therapeutics for flaviviral infections

AM Bifani, KWK Chan, D Borrenberghs, MJA Tan… - Antiviral Research, 2023 - Elsevier
Flaviviruses are vector-borne pathogens capable of causing devastating human diseases.
The re-emergence of Zika in 2016 notoriously led to a widescale epidemic in the Americas …

[HTML][HTML] Antiviral agents against flavivirus protease: prospect and future direction

SK Samrat, J Xu, Z Li, J Zhou, H Li - Pathogens, 2022 - mdpi.com
Flaviviruses cause a significant amount of mortality and morbidity, especially in regions
where they are endemic. A recent example is the outbreak of Zika virus throughout the …

[HTML][HTML] Repurposing of Doramectin as a New Anti-Zika Virus Agent

Y Zhu, M Liang, J Yu, B Zhang, G Zhu, Y Huang, Z He… - Viruses, 2023 - mdpi.com
Zika virus (ZIKV), belonging to the Flavivirus family and mainly transmitted by mosquitoes,
causes a variety of adverse outcomes, including Guillain-Barré syndrome, microcephaly …

[HTML][HTML] iPSC-derived three-dimensional brain organoid models and neurotropic viral infections

M Swingler, M Donadoni, A Bellizzi, S Cakir… - Journal of …, 2023 - Springer
Progress in stem cell research has revolutionized the medical field for more than two
decades. More recently, the discovery of induced pluripotent stem cells (iPSCs) has allowed …

Zafirlukast, as a viral inactivator, potently inhibits infection of several flaviviruses, including Zika virus, dengue virus, and yellow fever virus

Y Chen, Y Li, L Lu, P Zou - Antimicrobial Agents and …, 2024 - Am Soc Microbiol
Zika virus (ZIKV) is one of the mosquito-borne flaviviruses that exhibits a unique tropism to
nervous systems and is associated with Guillain-Barre syndrome and congenital Zika …

[HTML][HTML] Vector-Transmitted Flaviviruses: An Antiviral Molecules Overview

E Diani, A Lagni, V Lotti, E Tonon, R Cecchetto… - Microorganisms, 2023 - mdpi.com
Flaviviruses cause numerous pathologies in humans across a broad clinical spectrum with
potentially severe clinical manifestations, including hemorrhagic and neurological disorders …

The in vitro and in vivo antiviral effects of aloperine against Zika virus infection

P Zhou, Z Lao, H Long, P Pan, F Liao… - Journal of Medical …, 2023 - Wiley Online Library
Zika virus (ZIKV) infection poses a significant threat to global public health and is associated
with microcephaly. There are no approved ZIKV‐specific vaccines or drugs for the clinical …

[HTML][HTML] Structural Modifications Introduced by NS2B Cofactor Binding to the NS3 Protease of the Kyasanur Forest Disease Virus

S Kandagalla, B Kumbar, J Novak - International journal of molecular …, 2023 - mdpi.com
Kyasanur Forest Disease virus (KFDV), a neglected human pathogenic virus, is a Flavivirus
that causes severe hemorrhagic fever in humans. KFDV is transmitted to humans by the bite …

[HTML][HTML] Inhibitors of the RBD-ACE-2 Found among a Wide Range of Dyes by the Immunoassay Method

ED Mordvinova, PA Nikitina, OI Yarovaya… - Chemosensors, 2023 - mdpi.com
Angiotensin-converting enzyme 2 (ACE2), the functional receptor of SARS-CoV-2, plays a
crucial role in the pathogenesis of COVID-19. ACE2 targeting holds the promise for …

Mapping the scientific output of organoids for modeling animal and human infectious diseases: A bibliometric assessment

J Yan, C Cougoule, S Lacroix-Lamandé, A Wiedemann - 2023 - researchsquare.com
The escalation of antibiotic resistance, pandemics, and nosocomial infections underscores
the importance of research in both animal and human infectious diseases. Recent …