The modification of eukaryotic proteins by isoprenoid lipids, which is known as prenylation,
controls the localization and activity of a range of proteins that have crucial functions in …

The conserved serine/threonine kinase mTOR (the mammalian target of rapamycin), a
downstream effector of the PI3K/AKT pathway, forms two distinct multiprotein complexes …

Protein farnesylation and geranylgeranylation, together referred to as prenylation, are lipid
post-translational modifications that are required for the transforming activity of many …

Extensive research on the Ras proteins and their functions in cell physiology over the past
30 years has led to numerous insights that have revealed the involvement of Ras not only in …

Ribosomal protein S6 (RPS6) is a component of the 40S small ribosomal subunit and
participates in the control of mRNA translation. Additionally, phospho (p)-RPS6 has been …

The RAS oncogenes (HRAS, NRAS and KRAS) comprise the most frequently mutated class
of oncogenes in human cancers (33%), thus stimulating intensive effort in developing anti …

The involvement of the RAS superfamily of monomeric GTPases in carcinogenesis is
increasingly being appreciated. A complex array of post-translational modifications and a …

Apoptosis is a tightly regulated cell suicide program that plays an essential role in the
maintenance of tissue homeostasis by eliminating unnecessary or harmful cells. Defects in …

Some proteins undergo posttranslational modification by the addition of an isoprenyl lipid
(farnesyl-or geranylgeranyl-isoprenoid) to a cysteine residue proximal to the C terminus …

Acute myeloid leukemia (AML) involves a block in terminal differentiation of the myeloid
lineage and uncontrolled proliferation of a progenitor state. Using phorbol myristate acetate …