Plasminogen activator, urokinase (PLAU) is involved in cell migration, proliferation and
tissue remodeling. PLAU upregulation is associated with an increase in aggressiveness …

Epigenetic modifications play a crucial role in regulating gene expression patterns. Through
epigenetic editing approaches, the chromatin structure is modified and the activity of the …

To fully exploit the potentials of reprogramming the epigenome through CRISPR/dCas9
systems for epigenetic editing, there is a growing need for improved transfection methods …

Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is highly expressed in smokers, but little
is known about the molecular mechanism of UCHL1 in airway epithelium and its possible …

Epigenetic editing, an emerging technique used for the modulation of gene expression in
mammalian cells, is a promising strategy to correct disease-related gene expression …

To fully exploit the potentials of reprogramming the epigenome through CRISPR/Cas9
systems for epigenetic editing, there is a growing need for improved transfection methods …

Environmental exposure to cigarette smoke or toxic metal cadmium is closely associated
with various airway diseases, including lung cancer and chronic lung diseases. Ubiquitin …

For my PhD research we made use of Epigenetic Editing, a technique in which enzymes,
coupled to DNA-binding platforms, place or remove epigenetic marks at a specific piece of …

The introduction of the CRISPR/Cas9 system and its nuclease inactive variant dCas9 allows
us to address cause versus consequence relationships between biological phenomena …

Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is highly expressed in smokers, but little
is known about the molecular mechanism and the role of UCHL1 in airway epithelium …