The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …

Pluripotent stem cells underpin a growing sector that leverages their differentiation potential
for research, industry, and clinical applications. This review evaluates the landscape of …

Single-cell RNA-sequencing (scRNA-seq) is valuable for analyzing cellular heterogeneity.
Cell composition accuracy is critical for analyzing cell–cell interaction networks from scRNA …

Fibroblast activation is transient in successful wound repair but persistent in fibrotic
pathologies. Understanding fibroblast deactivation during successful wound healing may …

Rapid expansion of the pulmonary microvasculature through angiogenesis drives
alveolarization, the final stage of lung development that occurs postnatally and dramatically …

Hyperoxia disrupts lung development in mice and causes bronchopulmonary dysplasia
(BPD) in neonates. To investigate sex-dependent molecular and cellular programming …

Research into novel diagnostic techniques and targeted therapeutics in interstitial lung
disease (ILD) is moving the field toward increased precision and improved patient …

Lung epithelium, the lining that covers the inner surface of the respiratory tract, is directly
exposed to the environment and thus susceptible to airborne toxins, irritants, and pathogen …

Some previous studies in tissue fibrosis have suggested a profibrotic contribution from
elevated expression of a protein termed either RGCC (regulator of cell cycle) or RGC-32 …

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited
therapeutic options. The current model suggests that chronic or repetitive “micro-injuries” of …