Double diffusion encoding and applications for biomedical imaging

RN Henriques, M Palombo, SN Jespersen… - Journal of Neuroscience …, 2021 - Elsevier
Abstract Diffusion Magnetic Resonance Imaging (dMRI) is one of the most important
contemporary non-invasive modalities for probing tissue structure at the microscopic scale …

Imaging of cerebrovascular pathology in animal models of Alzheimer's disease

J Klohs, M Rudin, DR Shimshek… - Frontiers in aging …, 2014 - frontiersin.org
In Alzheimer's disease (AD), vascular pathology may interact with neurodegeneration and
thus aggravate cognitive decline. As the relationship between these two processes is poorly …

Tensor denoising of multidimensional MRI data

JL Olesen, A Ianus, L Østergaard… - Magnetic resonance …, 2023 - Wiley Online Library
Purpose To develop a denoising strategy leveraging redundancy in high‐dimensional data.
Theory and Methods The SNR fundamentally limits the information accessible by MRI. This …

Fiber-optic implant for simultaneous fluorescence-based calcium recordings and BOLD fMRI in mice

F Schlegel, Y Sych, A Schroeter, J Stobart, B Weber… - Nature protocols, 2018 - nature.com
Despite the growing popularity of blood oxygen level–dependent (BOLD) functional MRI
(fMRI), understanding of its underlying principles is still limited. This protocol describes a …

Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects

D Mircsof, M Langouet, M Rio, S Moutton… - Nature …, 2015 - nature.com
The NONO protein has been characterized as an important transcriptional regulator in
diverse cellular contexts. Here we show that loss of NONO function is a likely cause of …

Ultra High-Resolution In vivo Computed Tomography Imaging of Mouse Cerebrovasculature Using a Long Circulating Blood Pool Contrast Agent

Z Starosolski, CA Villamizar, D Rendon, MJ Paldino… - Scientific reports, 2015 - nature.com
Abnormalities in the cerebrovascular system play a central role in many neurologic
diseases. The on-going expansion of rodent models of human cerebrovascular diseases …

Cardiac light-sheet fluorescent microscopy for multi-scale and rapid imaging of architecture and function

P Fei, J Lee, RRS Packard, KI Sereti, H Xu, J Ma… - Scientific reports, 2016 - nature.com
Abstract Light Sheet Fluorescence Microscopy (LSFM) enables multi-dimensional and multi-
scale imaging via illuminating specimens with a separate thin sheet of laser. It allows rapid …

Oscillating gradient diffusion MRI reveals unique microstructural information in normal and hypoxia‐ischemia injured mouse brains

D Wu, LJ Martin, FJ Northington… - Magnetic resonance in …, 2014 - Wiley Online Library
Purpose We investigated whether oscillating gradient diffusion MRI (dMRI) can provide
information on brain microstructural changes after formaldehyde fixation and after hypoxic …

In vivo high-resolution diffusion tensor imaging of the mouse brain

D Wu, J Xu, MT McMahon, PCM van Zijl, S Mori… - Neuroimage, 2013 - Elsevier
Diffusion tensor imaging (DTI) of the laboratory mouse brain provides important macroscopic
information for anatomical characterization of mouse models in basic research. Currently, in …

In vivo microscopic voxel-based morphometry with a brain template to characterize strain-specific structures in the mouse brain

K Hikishima, Y Komaki, F Seki, Y Ohnishi, HJ Okano… - Scientific reports, 2017 - nature.com
Hundreds of inbred mouse strains are established for use in a broad spectrum of basic
research fields, including genetics, neuroscience, immunology, and cancer. Inbred mice …