Decades of research have identified genetic factors and biochemical pathways involved in
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …

Alzheimer's disease is a rather complex neurodegenerative disease, which is attributed to a
combination of multiple factors. Among the many pathological pathways, synaptic …

Microtubules are polarized cytoskeletal filaments that serve as tracks for intracellular
transport and form a scaffold that positions organelles and other cellular components and …

Human-induced pluripotent stem cells (hiPSCs) have emerged as a promising in vitro model
system for studying neurodevelopment. However, current models remain limited in their …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are associated with
loss of nuclear transactive response DNA-binding protein 43 (TDP-43). Here we identify that …

BACKGROUND Neurons are polarized cells with extreme geometries. Multiple dendrites
and one axon generally emerge from a single cell body and establish synaptic contacts with …

Microglial reactivity is a pathological hallmark in many neurodegenerative diseases. During
stimulation, microglia undergo complex morphological changes, including loss of their …

Microtubule-associated protein 2 (MAP2) is the predominant cytoskeletal regulator within
neuronal dendrites, abundant and specific enough to serve as a robust somatodendritic …

At the base of axons sits a unique compartment called the axon initial segment (AIS). The
AIS generates and shapes the action potential before it is propagated along the axon …

Handedness has been extensively studied because of its relationship with language and the
over-representation of left-handers in some neurodevelopmental disorders. Using data from …