Introduction Rapid advances in bioengineering enable the use of complex proteins as
therapeutic agents to treat diseases. Compared with conventional small molecule drugs …

Systems biology can be defined as the study of a biological process in which all of the
relevant components are investigated together in parallel to discover the mechanism …

Aquaporins (AQP) working as membrane channels facilitated water transport, play vital roles
in various physiological progress including cell migration, energy metabolism, inflammation …

HSK7653, an oral dipeptidyl peptidase-4 inhibitor administered every 2 weeks, is a
candidate for the treatment of type 2 diabetes mellitus. The major elimination pathway of …

Epigenetic regulation is a pivotal factor during neuroblastoma (NB) pathogenesis and
investigations into cancer epigenetics are actively underway to identify novel therapeutic …

Kidneys, one of the vital organs in our body, are responsible for maintaining whole body
homeostasis. The complexity of renal function (eg, filtration, reabsorption, fluid and …

Hyponatremia is the most common disorder of electrolyte imbalances. It is necessary to
develop new type of diuretics to treat hyponatremia without losing electrolytes. Urea …

Urea transporters (UTs) have been identified as new targets for diuretics. Functional deletion
of UTs led to urea-selective urinary concentrating defects with relative salt sparing. In our …

Backgrounds Crush syndrome (CS) is the leading cause of death after earthquakes, second
only to direct trauma. Acute kidney injury (AKI) is the most severe complication of CS …

Ascites is a typical symptom of liver cirrhosis that is caused by a variety of liver diseases.
Ascites severely affects the life quality of patients and needs long-term treatment. 25a is a …