Polysaccharide and polypeptide based injectable thermo-sensitive hydrogels for local biomedical applications

HF Darge, AT Andrgie, HC Tsai, JY Lai - International journal of biological …, 2019 - Elsevier
Injectable thermo-responsive hydrogels have been studied for various biomedical
applications including; drug delivery, cell encapsulation, and tissue repairing. There are …

Thiolated polymers: Bioinspired polymers utilizing one of the most important bridging structures in nature

C Leichner, M Jelkmann… - Advanced Drug Delivery …, 2019 - Elsevier
Thiolated polymers designated “thiomers” are obtained by covalent attachment of thiol
functionalities on the polymeric backbone of polymers. In 1998 these polymers were first …

Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke

LR Nih, S Gojgini, ST Carmichael, T Segura - Nature materials, 2018 - nature.com
Stroke is the primary cause of disability due to the brain's limited ability to regenerate
damaged tissue. After stroke, an increased inflammatory and immune response coupled …

Injectable AuNP-HA matrix with localized stiffness enhances the formation of gap junction in engrafted human induced pluripotent stem cell-derived cardiomyocytes …

H Li, B Yu, P Yang, J Zhan, X Fan, P Chen, X Liao… - Biomaterials, 2021 - Elsevier
Cell therapy offers a promising paradigm for heart tissue regeneration. Human induced
pluripotent stem cells (hiPS) and their cardiac derivatives are emerging as a novel treatment …

Human embryonic stem cell-derived neural stem cells encapsulated in hyaluronic acid promotes regeneration in a contusion spinal cord injured rat

M Zarei-Kheirabadi, H Sadrosadat… - International journal of …, 2020 - Elsevier
Abstract spinal cord injury (SCI) is a traumatic damage that can causes a loss of neurons
around the lesion site and resulting in locomotor and sensory deficits. Currently, there is …

Hyaluronic acid containing scaffolds ameliorate stem cell function for tissue repair and regeneration

G Agarwal, S Agiwal, A Srivastava - International Journal of Biological …, 2020 - Elsevier
Recent evidence based studies have proposed hyaluronic acid (HA) as an emerging
biopolymer for various tissue engineering application. Meanwhile, stem cells (SCs) have …

Three-dimensional hyaluronic acid hydrogel-based models for in vitro human iPSC-derived NPC culture and differentiation

S Wu, R Xu, B Duan, P Jiang - Journal of Materials Chemistry B, 2017 - pubs.rsc.org
Human induced pluripotent stem cell-derived neural progenitor cells (hiPSC-NPCs) are
considered as a promising cell source for transplantation and have been used for organoid …

Design and translation of injectable biomaterials

M Nguyen, M Karkanitsa, KL Christman - Nature Reviews …, 2024 - nature.com
Injectable biomaterials, including bulk materials and particulate materials, can be delivered
in a minimally invasive way and may provide alternative treatment options for conditions that …

Particle hydrogels decrease cerebral atrophy and attenuate astrocyte and microglia/macrophage reactivity after stroke

E Sideris, S Kioulaphides, KL Wilson, A Yu… - Advanced …, 2022 - Wiley Online Library
Increasing numbers of individuals live with stroke related disabilities. Following stroke,
highly reactive astrocytes and pro‐inflammatory microglia can release cytokines and lead to …

Brain repair mechanisms after cell therapy for stroke

R Rust, LR Nih, L Liberale, H Yin, M El Amki, LK Ong… - Brain, 2024 - academic.oup.com
Cell-based therapies hold great promise for brain repair after stroke. While accumulating
evidence confirms the preclinical and clinical benefits of cell therapies, the underlying …