On what motivates us: a detailed review of intrinsic v. extrinsic motivation

LS Morris, MM Grehl, SB Rutter, M Mehta… - Psychological …, 2022 - cambridge.org
Motivational processes underlie behaviors that enrich the human experience, and
impairments in motivation are commonly observed in psychiatric illness. While motivated …

Reward processing in depression: a conceptual and meta-analytic review across fMRI and EEG studies

H Keren, G O'Callaghan, P Vidal-Ribas… - American Journal of …, 2018 - Am Psychiatric Assoc
Objective: A role for aberrant reward processing in the pathogenesis of depression has long
been proposed. However, no review has yet examined its role in depression by integrating …

Brain structure alterations in depression: Psychoradiological evidence

FF Zhang, W Peng, JA Sweeney… - CNS neuroscience & …, 2018 - Wiley Online Library
Depression is the leading cause of disability around the world, but little is known about its
pathology. Currently, the diagnosis of depression is made based on clinical manifestations …

Cortico-striatal-thalamic loop circuits of the orbitofrontal cortex: promising therapeutic targets in psychiatric illness

P Fettes, L Schulze, J Downar - Frontiers in systems neuroscience, 2017 - frontiersin.org
Corticostriatal circuits through the orbitofrontal cortex (OFC) play key roles in complex
human behaviors such as evaluation, affect regulation and reward-based decision-making …

Serotonin neurons modulate learning rate through uncertainty

CD Grossman, BA Bari, JY Cohen - Current Biology, 2022 - cell.com
Regulating how fast to learn is critical for flexible behavior. Learning about the
consequences of actions should be slow in stable environments, but accelerate when that …

Distorted cognitive processes in major depression: A predictive processing perspective

T Kube, R Schwarting, L Rozenkrantz… - Biological …, 2020 - Elsevier
The cognitive model of depression has significantly influenced the understanding of
distorted cognitive processes in major depression; however, this model's conception of …

Characterizing anhedonia: A systematic review of neuroimaging across the subtypes of reward processing deficits in depression

A Borsini, ASJ Wallis, P Zunszain, CM Pariante… - Cognitive, Affective, & …, 2020 - Springer
Anhedonia is a key symptom of major depressive disorder (MDD) and comprises
behavioural deficits in three reward processing subtypes: reward liking, reward wanting, and …

Meta-analysis of reward processing in major depressive disorder reveals distinct abnormalities within the reward circuit

TH Ng, LB Alloy, DV Smith - Translational psychiatry, 2019 - nature.com
Many neuroimaging studies have investigated reward processing dysfunction in major
depressive disorder. These studies have led to the common idea that major depressive …

Roles of the medial and lateral orbitofrontal cortex in major depression and its treatment

B Zhang, ET Rolls, X Wang, C Xie, W Cheng… - Molecular …, 2024 - nature.com
We describe evidence for dissociable roles of the medial and lateral orbitofrontal cortex
(OFC) in major depressive disorder (MDD) from structure, functional activation, functional …

Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium

E Walton, DP Hibar, TGM Van Erp, SG Potkin… - Psychological …, 2018 - cambridge.org
BackgroundOur understanding of the complex relationship between schizophrenia
symptomatology and etiological factors can be improved by studying brain-based correlates …