Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with
intrinsic abilities to identify and eliminate virally infected cells and tumour cells. Possessing …

Tumor initiation, progression, and response to therapies depend to a great extent on
interactions between malignant cells and the tumor microenvironment (TME), which denotes …

Background Chimeric antigen receptor (CAR) T cell therapy has been successfully
translated to clinical practice for the treatment of B cell malignancies. The suppressive …

Tumor heterogeneity dominates tumor biological behavior and shapes the tumor
microenvironment. However, the mechanisms of tumor genetic features modulate immunity …

SUMOylation, which is a type of post-translational modification that involves covalent
conjugation of small ubiquitin-like modifier (SUMO) proteins to target substrates, regulates …

Acute myeloid leukemias (AML) are severe hematomalignancies with dismal prognosis. The
post-translational modification SUMOylation plays key roles in leukemogenesis and AML …

Protein SUMOylation is a major post-translational modification essential for maintaining
cellular homeostasis. SUMOylation has long been associated with stress responses as a …

Background Although immune checkpoint inhibitors (ICIs) have revolutionized the
landscape of cancer treatment, only a minority of colorectal cancer (CRC) patients respond …

Background The clinical response rate to immune checkpoint blockade (ICB) therapy in
melanoma remains low, despite its widespread use. Circular non-coding RNAs (circRNAs) …

Aberrant SUMOylation contributes to the progression of hepatocellular carcinoma (HCC), yet
the molecular mechanisms have not been well elucidated. RING-type E3 ubiquitin ligase …