The advent of induced pluripotent stem cells (iPSCs) has advanced our understanding of the
molecular mechanisms of human disease, drug discovery, and regenerative medicine. As …

Drug repurposing is the use of a given therapeutic agent for indications other than that for
which it was originally designed or intended. The concept is appealing because of …

A key therapeutic target for heart failure and arrhythmia is the deleterious leak through
sarcoplasmic reticulum (SR) ryanodine receptor 2 (RyR2) calcium release channels. We …

Thoracic aortic disease (TAD) is often silent until a life-threatening complication occurs.
However, genetic information can inform both identification and treatment at an early stage …

Prolongation of the cardiac action potential (AP) and early after depolarizations (EADs) are
electrical anomalies of cardiomyocytes that can lead to lethal arrhythmias and are potential …

From carrying potentially pathogenic genes to severe clinical phenotypes, the basic
research in the inherited cardiac ion channel disease such as long QT syndrome (LQTS) …

Heart disease is one of the top causes of healthcare expenses in the United States. Lethal
ventricular cardiac arrhythmia can arise in acquired or congenital heart disease. Long QT …

Abstract Purpose of Review Our understanding of the fundamental cellular and molecular
factors leading to atrial fibrillation (AF) remains stagnant despite significant advancement in …