This paper describes the synthesis of two amino-quinazolinediones which are potent
gyrase/topoisomerase inhibitors and useful as antibacterial agents. The early scale-up work …

Efficient synthesis of novel pyrido[3,2-d]pyrimidine-2,4-diones - ScienceDirect Skip to main
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Abstract Pyrido [3, 2-d] pyrimidine-2, 4-diones derivatives have been synthesized in good
yields by two efficient synthetic routes, the first one through an hetero-cyclization on the …

A series of novel 3-N-sugar-substituted quinazolinediones were synthesized through the
cyclization of the intermediate 2-aminobenzamides using triphosgene as the condensing …

A new series of substituted anthranilic esters derivatives linked with a 1, 3-dithiolane
andbenzyloximino moiety was synthesized using the simple esterfication reaction and …

In this thesis, twenty eight novel derivatives of 6, 7-disubstituted-3-{2-[4-(substituted)
piperazin-1-yl]-2-oxoethyl} quinazoline-2, 4 (1H, 3H)-dione (compound 7-34) have been …

Abstract Preparation of pyrazolo [3, 4-d] pyrimidines and pyrazolo [4, 3-d] pyrimidines were
made up via Curtius rearrangement of 4-methoxycarbonyl-1, 3-diphenyl-5-carboxypyrazole …

Après une attentive lecture de la littérature (cf. chapitre I), il ressort qu'il n'existe que très peu
de voies de synthèse et de fonctionnalisation du motif pyridopyrazolopyridazine. Ainsi nous …

La découverte de nouveaux candidats susceptibles de lutter contre différentes pathologies,
en l'occurrence le cancer et les maladies neurodégénératives, constitue l'un des principaux …

Le choix de la synthèse de nouveaux dérivés pyrido [3, 2-d] pyrimidines, comme sujet de
recherche, repose principalement sur l'intérêt médicinal des molécules ainsi élaborées. Les …