Inflammation and Wnt signaling: target for immunomodulatory therapy?

I Jridi, K Canté-Barrett, K Pike-Overzet… - Frontiers in cell and …, 2021 - frontiersin.org
Wnt proteins comprise a large family of highly conserved glycoproteins known for their role
in development, cell fate specification, tissue regeneration, and tissue homeostasis …

Neuroprotective effect of hydrogen sulfide subchronic treatment against tbi-induced ferroptosis and cognitive deficits mediated through wnt signaling pathway

J Chen, Z Chen, D Yu, Y Yan, X Hao, M Zhang… - Cellular and Molecular …, 2023 - Springer
Emerging evidence shows that targeting ferroptosis may be a potential therapeutic strategy
for treating traumatic brain injury (TBI). Hydrogen sulfide (H2S) has been proven to play a …

Research advances in Peyronie's disease: a comprehensive review on genomics, pathways, phenotypic manifestation, and therapeutic targets

J Chi, W Bi, K Lou, J Ma, J Wu… - Sexual Medicine Reviews, 2024 - academic.oup.com
Introduction Penile induration disease, commonly known as Peyronie's disease (PD), is a
connective tissue disorder that affects the penis, leading to the development of fibrous …

[HTML][HTML] Modeling human ectopic pregnancies with trophoblast and vascular organoids

X Zhao, Z Zhang, Q Zhu, Y Luo, Q Ye, S Shi, X He… - Cell Reports, 2023 - cell.com
Ruptured ectopic pregnancy (REP), a pregnancy complication caused by aberrant
implantation, deep invasion, and overgrowth of embryos in fallopian tubes, could lead to …

A CIC-related-epigenetic factors-based model associated with prediction, the tumor microenvironment and drug sensitivity in osteosarcoma

B Yu, C Geng, Z Wu, Z Zhang, A Zhang, Z Yang… - Scientific Reports, 2024 - nature.com
Osteosarcoma is generally considered a cold tumor and is characterized by epigenetic
alterations. Although tumor cells are surrounded by many immune cells such as …

Ocular Wnt/β-catenin pathway inhibitor XAV939-loaded liposomes for treating alkali-burned corneal wound and neovascularization

Y Zhong, K Wang, Y Zhang, Q Yin, S Li… - … in Bioengineering and …, 2021 - frontiersin.org
Corneal wound involves a series of complex and coordinated physiological processes,
leading to persistent epithelial defects and opacification. An obstacle in the treatment of …

Ginsenoside CK inhibits androgenetic alopecia by regulating Wnt/β‐catenin and p53 signaling pathways in AGA mice

C Fang, H Yang, C Zhu, D Fan, J Deng - Food Frontiers, 2023 - Wiley Online Library
Androgenetic alopecia (AGA) is one of the most common chronic skin diseases caused by
the destruction of androgens in the body. It is caused by the excessive deposition of …

Anti-Inflammatory Activity of Some Characteristic Constituents from the Vine Stems of Spatholobus suberectus

XY Liu, YB Zhang, XW Yang, YF Yang, W Xu, W Zhao… - Molecules, 2019 - mdpi.com
The dried vine stems of Spatholobus suberectus are commonly used in traditional Chinese
medicine for treating gynecological and cardiovascular diseases. In this study, five new …

Paeoniflorin suppresses the apoptosis and inflammation of human coronary artery endothelial cells induced by oxidized low-density lipoprotein by regulating the Wnt …

S Liu, Y Li, C Wu - Pharmaceutical Biology, 2023 - Taylor & Francis
Context Paeoniflorin (PF) contributes to improving coronary artery disease (CAD). Objective
This study clarified the efficiency of PF in CAD and the molecular mechanism. Materials and …

Integration of single-cell sequencing and bulk RNA-seq to identify and develop a prognostic signature related to colorectal cancer stem cells

J Wu, W Li, J Su, J Zheng, Y Liang, J Lin, B Xu… - Scientific Reports, 2024 - nature.com
The prognosis for patients with colorectal cancer (CRC) remains worse than expected due to
metastasis, recurrence, and resistance to chemotherapy. Colorectal cancer stem cells …