The TNF family of ligands and receptors: communication modules in the immune system and beyond
C Dostert, M Grusdat, E Letellier… - Physiological …, 2019 - journals.physiology.org
The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF)
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …
Mechanism of action of anti-TNF therapy in inflammatory bowel disease
AD Levin, ME Wildenberg… - Journal of Crohn's and …, 2016 - academic.oup.com
Several anti-tumour necrosis factor [TNF] blocking strategies have been evaluated in
patients with Crohn's disease. Compounds that have been tested included the full …
patients with Crohn's disease. Compounds that have been tested included the full …
Combined antiangiogenic and anti–PD-L1 therapy stimulates tumor immunity through HEV formation
Inhibitors of VEGF (vascular endothelial growth factor)/VEGFR2 (vascular endothelial growth
factor receptor 2) are commonly used in the clinic, but their beneficial effects are only …
factor receptor 2) are commonly used in the clinic, but their beneficial effects are only …
A human model of asthma exacerbation reveals transcriptional programs and cell circuits specific to allergic asthma
J Alladina, NP Smith, T Kooistra, K Slowikowski… - Science …, 2023 - science.org
Asthma is a chronic disease most commonly associated with allergy and type 2
inflammation. However, the mechanisms that link airway inflammation to the structural …
inflammation. However, the mechanisms that link airway inflammation to the structural …
Cytokines IL-17 and IL-22 in the host response to infection
M Valeri, M Raffatellu - Pathogens and disease, 2016 - academic.oup.com
Abstract Cytokines IL-17 and IL-22 play pivotal roles in host defense against microbes and
in the development of chronic inflammatory diseases. These cytokines are produced by cells …
in the development of chronic inflammatory diseases. These cytokines are produced by cells …
An IL-27-driven transcriptional network identifies regulators of IL-10 expression across T helper cell subsets
Summary Interleukin-27 (IL-27) is an immunoregulatory cytokine that suppresses
inflammation through multiple mechanisms, including induction of IL-10, but the …
inflammation through multiple mechanisms, including induction of IL-10, but the …
Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-β receptor
Pathogens have co-evolved with mosquitoes to optimize transmission to hosts. Mosquito
salivary-gland extract is known to modulate host immune responses and facilitate pathogen …
salivary-gland extract is known to modulate host immune responses and facilitate pathogen …
Inflammatory markers in anorexia nervosa: an exploratory study
Inflammation has been suggested to play a pathophysiological role in anorexia nervosa
(AN). In this exploratory cross-sectional study, we measured serum concentrations of 40 …
(AN). In this exploratory cross-sectional study, we measured serum concentrations of 40 …
An epithelial Nfkb2 pathway exacerbates intestinal inflammation by supplementing latent RelA dimers to the canonical NF-κB module
Aberrant inflammation, such as that associated with inflammatory bowel disease (IBD), is
fueled by the inordinate activity of RelA/NF-κB factors. As such, the canonical NF-κB module …
fueled by the inordinate activity of RelA/NF-κB factors. As such, the canonical NF-κB module …
A single-cell atlas of lymphocyte adaptive immune repertoires and transcriptomes reveals age-related differences in convalescent COVID-19 patients
F Bieberich, R Vazquez-Lombardi… - Frontiers in …, 2021 - frontiersin.org
COVID-19 disease outcome is highly dependent on adaptive immunity from T and B
lymphocytes, which play a critical role in the control, clearance and long-term protection …
lymphocytes, which play a critical role in the control, clearance and long-term protection …