Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the
enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has …

Paeoniflorin is a water-soluble monoterpenoid glycoside that can be derived from multiple
herbaceous plants, such as Radix Paeoniae Rubra, Radix Paeoniae Alba, Paeonia …

Novel N-benzylarylamide saderivatives were designed and synthesized, and their
antiproliferative activities were explored. Some of 51 target compounds exhibited potent …

Abstract Background The Hippo pathway is crucial in organ size control and tumorigenesis.
Dysregulation of the Hippo/YAP axis is commonly observed in gastric cancer, while effective …

The Hippo signaling pathway is highly conserved from Drosophila melanogaster to
mammals and plays a crucial role in organ size control, tissue regeneration, and tumor …

Abstract Background The Hippo pathway is widely considered to inhibit cell growth and play
an important role in regulating the size of organs. However, recent studies have shown that …

The Hippo pathway is generally understood to inhibit tumor growth by phosphorylating the
transcriptional cofactor YAP to sequester it to the cytoplasm and reduce the formation of YAP …

Tumor metastasis is one of the major factors for the high mortality in cholangiocarcinoma
(CCA), but its underlying mechanisms are not fully understood. Here, we report that Piezo …

Gastric cancer (GC), a common and high-mortality disease, still occupies an important
position in current cancer research, and Helicobacter pylori (H. pylori) infection as its …

Bonan Chen1, 2, 3†, Wai Nok Chan1, 2, 3†, Chun Wai Mui1, 2, 3†, Xiaoli Liu1, 2, 3, Jinglin
Zhang1, 2, 3, Yifei Wang1, 2, 3, Alvin HK Cheung1, Aden KY Chan1, Ronald CK Chan1 …