[HTML][HTML] Molecular mechanisms underlying vertebrate adaptive evolution: a systematic review

F Martínez Sosa, M Pilot - Genes, 2023 - mdpi.com
Adaptive evolution is a process in which variation that confers an evolutionary advantage in
a specific environmental context arises and is propagated through a population. When …

[HTML][HTML] Discerning evolutionary trends in post-translational modification and the effect of intrinsic disorder: analysis of methylation, acetylation and ubiquitination sites …

M Narasumani, PM Harrison - PLoS Computational Biology, 2018 - journals.plos.org
Intrinsically disordered regions (IDRs) of proteins play significant biological functional roles
despite lacking a well-defined 3D structure. For example, IDRs provide efficient housing for …

Sequence and structure‐based characterization of ubiquitination sites in human and yeast proteins using Chou's sample formulation

VS Kumar, A Vellaichamy - Proteins: Structure, Function, and …, 2019 - Wiley Online Library
Ubiquitination is an important post‐translational event responsible for half‐life and turnover
of proteins inside the cell. Proteins are ubiquitinated by forming an iso‐peptide bond …

Intrinsic disorder and posttranslational modification: an evolutionary perspective

PM Harrison - Structure and Intrinsic Disorder in Enzymology, 2023 - Elsevier
Intrinsically disordered regions (IDRs) in proteins are enriched in posttranslational
modifications (PTMs). Such PTMs evidence regulatory cross talk and are linked to …

[HTML][HTML] Evolutionary conservation of sequence motifs at sites of protein modification

S Li, HG Dohlman - Journal of Biological Chemistry, 2023 - ASBMB
Gene duplications are common in biology and are likely to be an important source of
functional diversification and specialization. The yeast Saccharomyces cerevisiae …

[HTML][HTML] Loss of conserved ubiquitylation sites in conserved proteins during human evolution

D Park, CJ Goh, H Kim, JS Lee… - … Journal of Molecular …, 2018 - spandidos-publications.com
Ubiquitylation of lysine residues in proteins serves a pivotal role in the efficient removal of
misfolded or unused proteins and in the control of various regulatory pathways by …