Method to diversify cyanine chromophore functionality enables improved biomolecule tracking and intracellular imaging

SM Usama, SC Marker, DH Li… - Journal of the …, 2023 - ACS Publications
Heptamethine indocyanines are invaluable probes for near-infrared (NIR) imaging. Despite
broad use, there are only a few synthetic methods to assemble these molecules, and each …

Photouncaging of Carboxylic Acids from Cyanine Dyes with Near‐Infrared Light

H Janeková, M Russo, U Ziegler… - Angewandte Chemie …, 2022 - Wiley Online Library
Abstract Near‐infrared light (NIR; 650–900 nm) offers unparalleled advantages as a
biocompatible stimulus. The development of photocages that operate in this region …

Light in a Heartbeat: Bond Scission by a Single Photon above 800 nm

M Russo, H Janeková, D Meier… - Journal of the …, 2024 - ACS Publications
Photocages enable scientists to take full control over the activity of molecules using light as
a biocompatible stimulus. Their emerging applications in photoactivated therapies call for …

Ratiometric near-infrared fluorescent probe for nitroreductase activity enables 3D imaging of hypoxic cells within intact tumor spheroids

JJ Morsby, Z Zhang, A Burchett, M Datta, BD Smith - Chemical Science, 2024 - pubs.rsc.org
Fluorescent molecular probes that report nitroreductase activity have promise as imaging
tools to elucidate the biology of hypoxic cells and report the past hypoxic history of …

A highly sensitive fluorescent HClO probe for discrimination between cancerous and normal cells/tissues

L Wang, J Liu, M Ren, W Guo - Chinese Chemical Letters, 2024 - Elsevier
Elevated level of hypochlorous acid (HClO) is closely associated with cancer development.
Identifying HClO level in cancer cells would provide important evidence in either early-stage …

A versatile fluorescent probe for simultaneously detecting viscosity, polarity and nitroreductases and its application in bioimaging

YL Qi, HR Wang, QJ Kang, LL Chen, PF Qi… - Sensors and Actuators B …, 2022 - Elsevier
Pathophysiological micro-environments such as viscosity, polarity and hypoxia are tightly
correlated with regulating diffusion, transportation, and intermolecular interactions in living …

Spin–Vibronic Control of Intersystem Crossing in Iodine-Substituted Heptamethine Cyanines

R Tovtik, E Muchova, L Štacková… - The Journal of …, 2023 - ACS Publications
Spin–orbit coupling between electronic states of different multiplicity can be strongly coupled
to molecular vibrations, and this interaction is becoming recognized as an important …

A fluorescence probe with targeted mitochondria was developed for detecting H2O2 in vitro and vivo

Y Tan, JR Wu, YR Wang, AH Zhang, JL Hu, XY Liu… - Microchemical …, 2024 - Elsevier
We designed and developed the probe P-1 for detecting H 2 O 2. The probe can selectively
detect H 2 O 2 with colorimetric change. In addition, the combination of portable test strips …

Cucurbit [7] uril Complexation of Near-Infrared Fluorescent Azobenzene-Cyanine Conjugates

SSR Kommidi, BD Smith - Molecules, 2022 - mdpi.com
Two new azobenzene heptamethine cyanine conjugates exist as dispersed monomeric
molecules in methanol solution and exhibit near-infrared (NIR) cyanine absorption and …

Monitoring Hg2+ ions in food and environmental matrices using a novel ratiometric NIR fluorescent sensor via carbonothioate-deprotection reaction

S Erdemir, S Malkondu, M Oguz, A Kocak - Environmental Pollution, 2024 - Elsevier
Mercury toxicity and its environmental impact are significant concerns for public health and
environmental protection. Therefore, the development of effective, rapid, and reliable …