2-Azabicyclo [2.2. 1] hept-5-en-3-one: chemical profile of a versatile synthetic building block and its impact on the development of therapeutics

R Singh, R Vince - Chemical Reviews, 2012 - ACS Publications
Replacement of the furanosyl oxygen with a methylene unit in the ribose sugar in
nucleosides 1 and nucleotides 2 prompted the rise of a new nucleoside class with very …

Cage-like amino alcohols. Synthesis, reactions, and application

LI Kas' yan, VA Pal'chikov - Russian journal of organic chemistry, 2010 - Springer
The review analyzes methods for the synthesis of amino alcohols containing cage-like
norbornene, norbornane, and adamantane fragments. Such reactions of amino alcohols as …

Synthesis of norbornane bisether antibiotics via silver-mediated alkylation

SM Hickey, TD Ashton, JM White, J Li, RL Nation… - RSC …, 2015 - pubs.rsc.org
A small series of norbornane bisether diguanidines have been synthesized and evaluated
as antibacterial agents. The key transformation—bisalkylation of norbornane diol 6—was not …

Enantioselective ethylation of aldehydes with 1, 3-N-donor ligands derived from (+)-camphoric acid

D Murtinho, MES Serra, AMAR Gonsalves - Tetrahedron: Asymmetry, 2010 - Elsevier
Derivatives of (+)-camphoric acid were prepared by a short and simple synthetic sequence
and proved to be excellent ligands for the enantioselective ethylation of benzaldehyde with …

Asymmetric addition of diethylzinc to aldehydes catalyzed by a camphor-derived β-amino alcohol

ZL Wu, HL Wu, PY Wu, BJ Uang - Tetrahedron: Asymmetry, 2009 - Elsevier
The asymmetric addition of diethylzinc to aromatic and aliphatic aldehydes, including linear
aliphatic ones, catalyzed by 2mol% of β-amino alcohol (1S, 2R)-7, 7-dimethyl-1-morpholin-4 …

Diastereoselective Hydroxymethylation of Cyclic N-tert-Butanesulfinylketimines Using Methoxymethanol as Formaldehyde Source

M Priede, M Kazak, T Kalnins, K Shubin… - The Journal of Organic …, 2014 - ACS Publications
Hydroxymethylation of cyclic tert-butanesulfinylketimine-derived lithium enamides with
methoxymethanol proceeds with excellent diastereoselectivity (99: 1 dr). Methoxymethanol …

Enantioselective alkylation of aromatic aldehydes with (+)-camphoric acid derived chiral 1, 3-diamine ligands

MES Serra, D Murtinho, V Paz - Tetrahedron: Asymmetry, 2017 - Elsevier
Abstract A series of chiral 1, 3-diamine ligands derived from (+)-camphoric acid were
prepared from the reaction of 1, 3-diamino-1, 2, 2-trimethylcyclopentane with aromatic …

Vasicine as tridentate ligand for enantioselective addition of diethylzinc to aldehydes

MA Aga, B Kumar, A Rouf, BA Shah, SC Taneja - Tetrahedron Letters, 2014 - Elsevier
The first report of natural l-vasicine as tridentate chiral ligand for the enantioselective
addition of diethylzinc to a variety of aliphatic and aromatic aldehydes is described. The …

Deciphering the mechanism behind efficient enantioselective ethylation with thiazolidine‐based amino alcohols

NCT Tavares, VRG Cacho, DCS Costa… - Applied …, 2022 - Wiley Online Library
Taking advantage of the opposite chirality of two privileged starting materials, l‐cysteine and
d‐penicillamine, a wide range of thiazolidine‐based amino alcohols was synthesized. l …

Asymmetric synthesis of novel 1, 4-aminoalcohol ligands with norbornene and norbornane backbone: use in the asymmetric diethylzinc addition to benzaldehyde

C Tanyeli, S Odabaş, M Erdem, E Çakır… - Tetrahedron: Asymmetry, 2007 - Elsevier
The asymmetric synthesis of cis-1, 4-aminoalcohols with norbornene and norbornane
backbone was performed starting with (2S, 3R)-(−)-cis-hemiester 1 (98% ee) …