Oxidative stress is one of the hallmarks of cancer. Tumorigenesis and progression are
accompanied by elevated reactive oxygen species (ROS) levels and adaptive elevation of …

B cells use unconventional strategies for the production of a seemingly unlimited number of
antibodies from a very limited amount of DNA. These methods dramatically increase the …

While the concept of Quality-by-Design is addressed at the upstream and downstream
process development stages, we questioned whether there are advantages to addressing …

Immunoglobulin G (IgG) antibodies are symmetrical molecules that may be regarded as
covalent dimers of 2 half-molecules, each consisting of a light chain and a heavy chain …

Monoclonal antibodies (mAbs) and their derivatives are currently the fastest growing class of
therapeutics. Even if naked antibodies have proven their value as successful …

Oral immunoglobulin (Ig) preparations are prime examples of medicinal nutrition from
natural sources. Plasma products containing Ig have been used for decades in animal feed …

Serum monoclonal immunoglobulin (Ig) is the main diagnostic factor for patients with
multiple myeloma (MM), however its prognostic potential remains unclear. On a large MM …

One of the basic structural features of human IgG1 is the arrangement of the disulfide bond
structure, 4 inter chain disulfide bonds in the hinge region and 12 intra chain disulfide bonds …

High‐resolution capillary zone electrophoresis–mass spectrometry (CZE‐MS) has been of
increasing interest for the analysis of biopharmaceuticals. In this work, a combination of …

Circular dichroism (CD) spectroscopy is routinely used in the biopharmaceutical industry to
study the effects of manufacturing, formulation, and storage conditions on protein …