Preeclampsia (PE), a hypertensive disorder of pregnancy, is increasing as a major
contributor to perinatal and long-term morbidity of mother and offspring. PE is thought to …

Oxidized LDLs (oxLDLs) and oxysterols play a key role in endothelial dysfunction and the
development of atherosclerosis. The loss of vascular endothelium function negatively …

Disturbances in endoplasmic reticulum (ER) function lead to ER stress which, when severe
or prolonged, may result in apoptosis. Severe ER stress has been implicated in several …

Background High-altitude cerebral edema (HACE) is a serious and potentially fatal brain
injury that is caused by acute hypobaric hypoxia (HH) exposure. Vasogenic edema is the …

Hemorrhagic shock (HS) often renders patients more susceptible to lung injury by priming
for an exaggerated response to a second infectious stimulus. Acute lung injury (ALI) is a …

Fetal growth restriction (FGR) and stillbirth are associated with placental dysfunction and
inflammation and hypoxia, oxidative and nitrative stress are implicated in placental damage …

Macrophage migration inhibitory factor (MIF) is up-regulated in diverse solid tumors and acts
as the critical link between immune response and tumorigenesis. In this study, we …

Understanding of sterile inflammation and its associated biological triggers and diseases is
still at the elementary stage. This becomes more warranted in cases where infections are not …

HMGB1 that belongs to the High Mobility Group-box superfamily, is a nonhistone chromatin
associated transcription factor. It is present in the nucleus of eukaryotes and can be actively …

High-mobility group box 1 (HMGB1) contributes to lung vascular hyperpermeability during
ventilator-induced lung injury. We aimed to determine whether the natural antioxidant …