Anti-dengue infectivity evaluation of bioflavonoid from Azadirachta indica by dengue virus serine protease inhibition
Dengue virus (DENV) serine protease enzyme, ie NS2B-NS3pro (non-structural protein 2B-
non-structural protein 3) has been approved as prime drug target for the drug discovery …
non-structural protein 3) has been approved as prime drug target for the drug discovery …
The importance of paying attention to the role of lipid-lowering drugs in controlling dengue virus infection
OQB Allela, M Ghazanfari Hashemi, SM Heidari… - Virology Journal, 2024 - Springer
The Flaviviridae family includes the dengue virus (DENV). About half of the world's
population is in danger because of the estimated 390 million infections and 96 million …
population is in danger because of the estimated 390 million infections and 96 million …
[HTML][HTML] Porcine reproductive and respiratory syndrome virus nsp4 positively regulates cellular cholesterol to inhibit type I interferon production
W Ke, Y Zhou, Y Lai, S Long, L Fang, S Xiao - Redox Biology, 2022 - Elsevier
Cellular cholesterol plays an important role in the life cycles of enveloped viruses. Previous
studies by our group and other groups have demonstrated that the depletion of cellular …
studies by our group and other groups have demonstrated that the depletion of cellular …
Engineering of HIV-1 neutralizing antibody CAP256V2LS for manufacturability and improved half life
B Zhang, D Gollapudi, J Gorman, S O'Dell… - Scientific reports, 2022 - nature.com
The broadly neutralizing antibody (bNAb) CAP256-VRC26. 25 has exceptional potency
against HIV-1 and has been considered for clinical use. During the characterization and …
against HIV-1 and has been considered for clinical use. During the characterization and …
A Synthetic Bioactive Peptide Derived from the Asian Medicinal Plant Acacia catechu Binds to Dengue Virus and Inhibits Cell Entry
A Panya, N Sawasdee, P Songprakhon, Y Tragoolpua… - Viruses, 2020 - mdpi.com
Dengue virus (DENV) infection has become a critically important globally prevalent
infectious disease, especially in tropical and subtropical countries. Since neither currently …
infectious disease, especially in tropical and subtropical countries. Since neither currently …
Analytical characterization of broadly neutralizing antibody CAP256LS heavy chain clipping during manufacturing development
D Gollapudi, E Rosales‐Zavala, VB Ivleva… - Biotechnology …, 2022 - Wiley Online Library
Broadly neutralizing antibody (bNAb) CAP256‐VRC26. 25 (abbreviated CAP256LS), a
human IgGI monoclonal antibody targeting the V1V2 site of the HIV‐1 envelope, has …
human IgGI monoclonal antibody targeting the V1V2 site of the HIV‐1 envelope, has …
[PDF][PDF] Investigations of cellular determinants involved in the entry process of bovine and porcine pestiviruses
ES Leveringhaus - 2022 - elib.tiho-hannover.de
The family Flaviviridae comprises small, enveloped viruses with a ribonucleic acid (RNA)
genome. The virions are 40-60 nm in size, of spherical shape and possess a lipid envelope …
genome. The virions are 40-60 nm in size, of spherical shape and possess a lipid envelope …
Pharmacological Manipulation of UPR: Potential Antiviral Strategy Against Chikungunya Virus
N Agrawal, S Saini, M Khanna, G Dhawan… - Indian Journal of …, 2022 - Springer
Viruses invade the host cells and maneuver the cellular translation machinery to translate
the viral proteins in substantial amounts, which may disturb Endoplasmic Reticulum …
the viral proteins in substantial amounts, which may disturb Endoplasmic Reticulum …
[HTML][HTML] Exploring Host Factors of the Human Metabolism as Promising Targets for Dengue Treatment
NC Tavares, CS Nascimento, JG de Oliveira… - 2024 - intechopen.com
The absence of specific therapy and the challenges posed by currently available palliative
drugs, such as paracetamol, underscore the urgent need for targeting medications against …
drugs, such as paracetamol, underscore the urgent need for targeting medications against …
Phage-Related Ribosomal Proteases (Prps): Discovery, Bioinformatics, and Structural Analysis
JA Hotinger, AH Gallagher, AE May - Antibiotics, 2022 - mdpi.com
Many new antimicrobials are analogs of existing drugs, sharing the same targets and
mechanisms of action. New antibiotic targets are critically needed to combat the growing …
mechanisms of action. New antibiotic targets are critically needed to combat the growing …