Abstract Phosphatidylinositol 4, 5-bisphosphate [PI (4, 5) P 2] is a minor lipid of the inner
leaflet of the plasma membrane that controls the activity of numerous proteins and serves as …

Talin is a large cytoskeletal protein (2541 amino acid residues) which plays a key role in
integrin-mediated events that are crucial for cell adhesion, migration, proliferation and …

Talin (tln) binds and activates integrins to couple extracellular matrix–bound integrins to the
cytoskeleton; however, its role in heart development is not well characterized. We identified …

Adhesion receptors play diverse roles during animal development and require precise
spatiotemporal regulation, which is achieved through the activity of their binding partners …

Transmembrane adhesion receptors, such as integrins, mediate cell adhesion by interacting
with intracellular proteins that connect to the cytoskeleton. Talin, one such linker protein, is …

Molecular replacement is one of the key methods used to solve the problem of determining
the phases of structure factors in protein structure solution from X-ray image diffraction data …

The cytoskeletal protein talin activates integrin receptors by binding of its FERM domain to
the cytoplasmic tail of β‐integrin. Talin also couples integrins to the actin cytoskeleton …

Neutrophil spreading is an essential process in neutrophil extravasation and is a key step in
the process of inflammation. Inhibition of neutrophil spreading is therefore a potential …

Abstract The United States of America, among many other countries around the world, is
suffering from lipid-related disorders. Developing treatment options for these disorders that …

The morphogenesis and maintenance of three-dimensional tissue architecture requires
intricate, coordinated regulation of cell shape, position, and proliferation. Cell adhesion …