Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate
vast protein diversity from a limited number of genes. The mechanisms and outcomes of …

Dilated cardiomyopathy (DCM) is a leading cause of heart failure, sudden cardiac death and
heart transplant. DCM is inherited in approximately 50% of cases, in which the most frequent …

Background: Each of the cardiomyopathies, classically categorized as hypertrophic
cardiomyopathy, dilated cardiomyopathy (DCM), and arrhythmogenic right ventricular …

Aim Numerous genes are known to cause dilated cardiomyopathy (DCM). However, until
now technological limitations have hindered elucidation of the contribution of all clinically …

Background: Mutations in RBM20 (RNA-binding motif protein 20) cause a clinically
aggressive form of dilated cardiomyopathy, with an increased risk of malignant ventricular …

Background Clinical interpretation of the large number of rare variants identified by high
throughput sequencing (HTS) technologies is challenging. The aim of this study was to …

Ribonucleoprotein (RNP) granules are biomolecular condensates—liquid–liquid phase-
separated droplets that organize and manage messenger RNA metabolism, cell signaling …

Heart failure is a major health burden, affecting 40 million people globally. One of the main
causes of systolic heart failure is dilated cardiomyopathy (DCM), the leading global …

The RNA-binding protein QKI belongs to the hnRNP K-homology domain protein family, a
well-known regulator of pre-mRNA alternative splicing and is associated with several …

It is 35 years since the first description of arrhythmogenic right ventricular cardiomyopathy
(ARVC) and more than 20 years since the first reports establishing desmosomal gene …