Longer human lives have led to a global burden of late-life disease. However, some older
people experience little ill health, a trait that should be extended to the general population …

The gut microbiota (GM) is a complex, evolutionarily molded ecological system, which
contributes to a variety of physiological functions. The GM is highly dynamic, being sensitive …

This article challenges the idea that cancer cannot be prevented among older adults by
examining different aspects of the relationship between age and cancer. Although the …

Longevity and healthy aging are among the most complex phenotypes studied to date. The
heritability of age at death in adulthood is approximately 25%. Studies of exceptionally long …

Like most complex phenotypes, exceptional longevity is thought to reflect a combined
influence of environmental (eg, lifestyle choices, where we live) and genetic factors. To …

BACKGROUND & AIMS: The prevalence of non-alcoholic fatty liver disease (NAFLD)
appears to increase with age. However, limited data are available concerning the …

Only two genome-wide significant loci associated with longevity have been identified so far,
probably because of insufficient sample sizes of centenarians, whose genomes may harbor …

Inflamm-aging, that is the age-associated inflammatory status, is considered one of the most
striking consequences of immunosenescence, as it is believed to be linked to the majority of …

Circulating microRNAs (miRs) have been investigated as diagnostic/prognostic biomarkers
in human diseases. However, little is known about their expression throughout the aging …

This study was aimed at characterizing the gut microbiota (GM) and its functional profile in
two groups of Sardinian subjects with a long healthy life expectancy, overall named Long …