The present review summarizes publications on the artemisinin peroxide fragment synthesis
from 1983 to 2016. The data are classified according to the structures of a precursor used in …

Covering: up to 2014 In the developing world, multi-drug resistant malaria caused by the
parasite Plasmodium falciparum is an epidemic that claims the lives of 1–3 million people …

Current developments in the burgeoning area of cooperative asymmetric catalysis indicate
the use of N-heterocyclic carbenes (NHCs) in conjunction with other catalysts such as a …

One of the rare alternative reagents for the reduction of carbon–carbon double bonds is
diimide (HN NH), which can be generated in situ from hydrazine hydrate (N2H4⋅ H2O) …

Conspectus Computational chemistry has made a sustained contribution to the
understanding of chemical reactions. In earlier times, half a century ago, the goal was to …

A transition-metal-free multicomponent coupling cyclization reaction was explored involving
arynes, tosylhydrazine, and α-bromo ketones. The reaction proceeds via a formal [2+ 2+ 2] …

The development of a cost-effective process for the production of artemisinin, the precursor
of all artemisinin-derived drugs, the first-line treatment for malaria, has been a long-pursued …

Two diastereomeric crystalline steroid dimers were obtained by acid-catalyzed double
acetalization of (20S)-5α-pregnan-3β, 16β, 20-triol 3-monoacetate with terephtalaldehyde …

This rosarium article relates the adventure started 50 years ago of a computational chemist
who was interested in molecules; what are they, what are their shape and how do they react …

Artemisinin, a natural sesquiterpene isolated from the Artemisia annua L. plant, represents a
remarkable achievement in the treatment against malaria. Since its discovery in the 1970's …