Transfer RNA modifications: nature's combinatorial chemistry playground
JE Jackman, JD Alfonzo - Wiley Interdisciplinary Reviews: RNA, 2013 - Wiley Online Library
Following synthesis, tRNAs are peppered by numerous chemical modifications which may
differentially affect a tRNA's structure and function. Although modifications affecting the …
differentially affect a tRNA's structure and function. Although modifications affecting the …
Mechanism and biological role of Dnmt2 in nucleic acid methylation
A Jeltsch, A Ehrenhofer-Murray, TP Jurkowski… - RNA biology, 2017 - Taylor & Francis
ABSTRACT A group of homologous nucleic acid modification enzymes called Dnmt2,
Trdmt1, Pmt1, DnmA, and Ehmet in different model organisms catalyze the transfer of a …
Trdmt1, Pmt1, DnmA, and Ehmet in different model organisms catalyze the transfer of a …
Structure and function of noncanonical nucleobases
T Carell, C Brandmayr, A Hienzsch… - Angewandte Chemie …, 2012 - Wiley Online Library
DNA and RNA contain, next to the four canonical nucleobases, a number of modified
nucleosides that extend their chemical information content. RNA is particularly rich in …
nucleosides that extend their chemical information content. RNA is particularly rich in …
[图书][B] DNA and RNA modification enzymes: structure, mechanism, function and evolution
H Grosjean - 2009 - taylorfrancis.com
This volume is a timely and comprehensive description of the many facets of DNA and RNA
modification-editing processes and to some extent repair mechanisms. Each chapter offers …
modification-editing processes and to some extent repair mechanisms. Each chapter offers …
Modification and editing of RNA: historical overview and important facts to remember
H Grosjean - Fine-tuning of RNA Functions by Modification and …, 2005 - Springer
RNA plays a central role in many cellular processes and several peculiarities of RNAs are
probably relics of an ancient primordial RNA World. To fulfill their multiple present-day …
probably relics of an ancient primordial RNA World. To fulfill their multiple present-day …
Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine
M Müller, M Hartmann, I Schuster, S Bender… - Nucleic acids …, 2015 - academic.oup.com
Dnmt2 enzymes are cytosine-5 methyltransferases that methylate C38 of several tRNAs. We
report here that the activities of two Dnmt2 homologs, Pmt1 from Schizosaccharomyces …
report here that the activities of two Dnmt2 homologs, Pmt1 from Schizosaccharomyces …
Structural Insights into riboswitch control of the biosynthesis of queuosine, a modified nucleotide found in the anticodon of tRNA
M Kang, R Peterson, J Feigon - Molecular cell, 2009 - cell.com
The modified nucleotide queuosine (Q) is almost universally found in the anticodon wobble
position of specific tRNAs. In many bacteria, biosynthesis of Q is modulated by a class of …
position of specific tRNAs. In many bacteria, biosynthesis of Q is modulated by a class of …
Queuosine modification of tRNA: its divergent role in cellular machinery
tRNAs possess a high content of modified nucleosides, which display an incredible
structural variety. These modified nucleosides are conserved in their sequence and have …
structural variety. These modified nucleosides are conserved in their sequence and have …
Site-specific covalent labeling of RNA by enzymatic transglycosylation
SC Alexander, KN Busby, CM Cole… - Journal of the …, 2015 - ACS Publications
We demonstrate the site-specific incorporation of nucleobase derivatives bearing
fluorophores or affinity labels into a short RNA stem loop recognition motif by exchange of a …
fluorophores or affinity labels into a short RNA stem loop recognition motif by exchange of a …
Evolving insights into RNA modifications and their functional diversity in the brain
In this Perspective, we expand the notion of temporal regulation of RNA in the brain and
propose that the qualitative nature of RNA and its metabolism, together with RNA …
propose that the qualitative nature of RNA and its metabolism, together with RNA …