Network Medicine applies network science approaches to investigate disease
pathogenesis. Many different analytical methods have been used to infer relevant molecular …

Cytoscape is open-source software for integration, visualization and analysis of biological
networks. It can be extended through Cytoscape plugins, enabling a broad community of …

Cumulative data link cytokine storms with coronavirus disease 2019 (COVID-19) severity.
The precise identification of immune cell subsets in bronchoalveolar lavage (BAL) and their …

Abstract Pathway Commons (https://www. pathwaycommons. org) is an integrated resource
of publicly available information about biological pathways including biochemical reactions …

Delineating hierarchical cellular states, including rare intermediates and the networks of
regulatory genes that orchestrate cell-type specification, are continuing challenges for …

Methods for single-cell RNA sequencing (scRNA-seq) have greatly advanced in recent
years. While droplet-and well-based methods have increased the capture frequency of cells …

Objective Systemic juvenile idiopathic arthritis (JIA) is associated with a recently recognized,
albeit poorly defined and characterized, lung disease (LD). The objective of this study was to …

Organismal function is, to a great extent, determined by interactions among their
fundamental building blocks, the cells. In this work, we studied the cell-cell interactome of …

DNA methylation dynamics influence brain function and are altered in neurological
disorders. 5-hydroxymethylcytosine (5-hmC), a DNA base that is derived from 5 …

Emerging evidence suggests a key contribution to non-alcoholic fatty liver disease (NAFLD)
pathogenesis by Th17 cells. The pathogenic characteristics and mechanisms of hepatic …