The proportion of different BCR-ABL1 transcript types in chronic myeloid leukemia. An international overview

M Baccarani, F Castagnetti, G Gugliotta, G Rosti… - Leukemia, 2019 - nature.com
There are different BCR-ABL1 fusion genes that are translated into proteins that are different
from each other, yet all leukemogenic, causing chronic myeloid leukemia (CML) or acute …

HDAC6—an emerging target against chronic myeloid leukemia?

H Losson, M Schnekenburger, M Dicato, M Diederich - Cancers, 2020 - mdpi.com
Imatinib became the standard treatment for chronic myeloid leukemia (CML) about 20 years
ago, which was a major breakthrough in stabilizing the pathology and improving the quality …

Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib

A Leyte-Vidal, RA DeFilippis, IR Outhwaite, I Kwan… - Leukemia, 2024 - nature.com
The recently approved BCR:: ABL1 tyrosine kinase inhibitor (TKI) asciminib has
demonstrated considerable activity and tolerability in newly diagnosed chronic phase …

Frequency of rare BCR‐ABL1 fusion transcripts in chronic myeloid leukemia patients

AK Arun, A Senthamizhselvi, S Mani… - International Journal …, 2017 - Wiley Online Library
Introduction The hallmark of chronic myeloid leukemia (CML) is the presence of
Philadelphia chromosome, its resultant fusion transcript (BCR‐ABL 1), and fusion protein …

[PDF][PDF] Correlation of p210 BCR-ABL transcript variants with clinical, parameters and disease outcome in 45 chronic myeloid leukemia patients

W Al-Achkar, F Moassass, N Youssef, A Wafa - J BUON, 2016 - researchgate.net
Purpose: The aim of this study was to search the BCR/ABL 1 fusion gene in 45 chronic
myeloid leukemia (CML) Syrian patients using nested reverse transcription polymerase …

The impact of BCR‐ABL1 transcript type on tyrosine kinase inhibitor responses and outcomes in patients with chronic myeloid leukemia

A Ercaliskan, AE Eskazan - Cancer, 2018 - Wiley Online Library
Although the majority of patients with chronic myeloid leukemia do well with treatment with
tyrosine kinase inhibitors (TKIs), some patients still have inferior outcomes. There are many …

Analysis of the clinico-hematological relevance of the breakpoint location within M-BCR in chronic myeloid leukemia

A Bennour, I Ouahchi, B Achour, M Zaier, YB Youssef… - Medical oncology, 2013 - Springer
Abstract The Philadelphia chromosome (Ph) derives from the balanced translocation
between chromosomes 9 and 22. This chromosomal translocation results in the fusion …

A study to determine the clinical, hematological, cytogenetic, and molecular profile in CML patient in and around Eastern UP, India

S Kumar, VK Gupta, A Bharti, LP Meena… - Journal of family …, 2019 - journals.lww.com
Objectives: A study to determine the clinical, hematological, cytogenetic, and molecular
profile in chronic myeloid leukemia (CML) patient in and around Eastern UP, India. Materials …

[PDF][PDF] The epidemiology of chronic myeloid leukaemia in southern Sarawak, Borneo Island

JW Kuan, S Melaine Michael - Med J Malaysia, 2018 - e-mjm.org
Objectives: There are very few published chronic myeloid leukaemia (CML) epidemiology
studies in South-East Asia and no representative from Malaysia. Methods: This is a cross …

Frequencies of BCR-ABL1 fusion transcripts among Sudanese chronic myeloid leukaemia patients

EAI Osman, K Hamad, IMF Elmula… - Genetics and molecular …, 2010 - SciELO Brasil
The incidence of one or other rearrangement in chronic myeloid leukemia (CML) patients
varies in different reported series. In this study we report the frequencies of BCR-ABL1 …