Organoboron compounds have a wide-range of applications in synthetic methodologies,
natural products, and bioactive molecule synthesis. The sensitivity of boronic acid toward …

Over the last century, nucleoside-based therapeutics have demonstrated remarkable
effectiveness in the treatment of a wide variety of diseases from cancer to HIV. In addition …

The hydroboration reaction involves the addition of BH bonds to sites of unsaturation and
provides an elegant route to reduce alkenes, alkynes, ketones, aldehydes, aldimines, etc …

The synthesis and utility of three benzoxaborole protecting groups are reported. These
protecting groups improve organic solubility and allow otherwise incompatible reactions …

Drug resistance in bacteria is a serious threat, and drugs with novel modes of action are
constantly needed. Fosmidomycin is a naturally occurring antibiotic that inhibits the …

Boronic acid protecting groups have revolutionized the use of organoborons in synthetic
chemistry, enabling organoboron functional groups to be carried through multistep …

The synthesis of small molecule natural products has long captivated the attention of
chemists and has generally proceeded via custom solutions to specific molecules. We …

This thesis will describe the development of two transition metal catalyzed syntheses of
organoboronic compounds. The first section describes relevant concepts and precedents for …

The leading infectious disease threat in the world is tuberculosis (TB) caused by the
bacterium Mycobacterium tuberculosis (M. tuberculosis). Although TB is preventable and …

I: Studies Toward the Total Synthesis of (-)-Apoptolidin A II: Bone Targeted Bis-phosphonate
Conjugates with Releasable Payloads Page 1 I: Studies Toward the Total Synthesis of (-)-Apoptolidin …