Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins

T Herdegen, JD Leah - Brain research reviews, 1998 - Elsevier
This article reviews findings up to the end of 1997 about the inducible transcription factors
(ITFs) c-Jun, JunB, JunD, c-Fos, FosB, Fra-1, Fra-2, Krox-20 (Egr-2) and Krox-24 (NGFI-A …

GDNF synthesis, signaling, and retrograde transport in motor neurons

AF Cintrón-Colón, G Almeida-Alves, AM Boynton… - Cell and tissue …, 2020 - Springer
Glial cell line–derived neurotrophic factor (GDNF) is a 134 amino acid protein belonging in
the GDNF family ligands (GFLs). GDNF was originally isolated from rat glial cell lines and …

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

Z Xia, M Dickens, J Raingeaud, RJ Davis… - Science, 1995 - science.org
Apoptosis plays an important role during neuronal development, and defects in apoptosis
may underlie various neurodegenerative disorders. To characterize molecular mechanisms …

FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

J Gilley, PJ Coffer, J Ham - The Journal of cell biology, 2003 - rupress.org
Developing sympathetic neurons die by apoptosis when deprived of NGF. BIM, a BH3-only
member of the BCL-2 family, is induced after NGF withdrawal in these cells and contributes …

[HTML][HTML] Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: a perspective on the contributions of apoptosis and necrosis

LJ Martin, NA Al-Abdulla, AM Brambrink, JR Kirsch… - Brain research …, 1998 - Elsevier
In the human brain and spinal cord, neurons degenerate after acute insults (eg, stroke,
cardiac arrest, trauma) and during progressive, adult-onset diseases [eg, amyotrophic lateral …

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1α to the endoplasmic reticulum and promotes dephosphorylation of the α …

MH Brush, DC Weiser, S Shenolikar - Molecular and cellular …, 2003 - Am Soc Microbiol
The growth arrest and DNA damage-inducible protein, GADD34, associates with protein
phosphatase 1 (PP1) and promotes in vitro dephosphorylation of the α subunit of eukaryotic …

The role of neuronal growth factors in neurodegenerative disorders of the human brain

B Connor, M Dragunow - Brain Research Reviews, 1998 - Elsevier
Recent evidence suggests that neurotrophic factors that promote the survival or
differentiation of developing neurons may also protect mature neurons from neuronal …

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia

H Xia, Q Mao, SL Eliason, SQ Harper, IH Martins… - Nature medicine, 2004 - nature.com
The dominant polyglutamine expansion diseases, which include spinocerebellar ataxia type
1 (SCA1) and Huntington disease, are progressive, untreatable, neurodegenerative …

Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation

JC Mills, NL Stone, J Erhardt, RN Pittman - The Journal of cell biology, 1998 - rupress.org
The evolutionarily conserved execution phase of apoptosis is defined by characteristic
changes occurring during the final stages of death; specifically cell shrinkage, dynamic …

Bcl-2 gene family in the nervous system

DE Merry, SJ Korsmeyer - Annual review of neuroscience, 1997 - annualreviews.org
▪ Abstract A growing family of genes that share homology with the bcl-2 proto-oncogene is
involved in the regulation of cell death. Many of these proteins show widespread expression …