Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

The ability to detect stimuli from the environment plays a pivotal role in our survival. The
molecules that allow the detection of such signals include ion channels, which are proteins …

Cannabidiol (CBD), as a major phytocannabinoid of Cannabis sativa, has emerged as a
promising natural compound in the treatment of diseases. Its diverse pharmacological …

Ion channels are membrane proteins expressed in almost all living cells. The sequencing of
the human genome has identified more than 400 putative ion channels, but only a fraction of …

The transient receptor potential (TRP) superfamily consists of a large number of
nonselective cation channels with variable degree of Ca2+-permeability. The 28 mammalian …

Numerous studies demonstrated that membrane cholesterol is a major regulator of ion
channel function. The goal of this review is to discuss significant advances that have been …

As described in the literature the interaction between cholesterol and membrane proteins
can occur via direct, ligand-like and indirect mechanisms, in which cholesterol effects are …

Abstract Transient Receptor Potential channels from the vanilloid subfamily (TRPV) are a
group of cation channels modulated by a variety of endogenous stimuli as well as a range of …

The transient receptor potential vanilloid 2 (TRPV2) ion channel is a polymodal receptor
widely involved in many physiological and pathological processes. Despite many TRPV2 …

Cloning of the transient receptor potential vanilloid type 1 (TRPV1), the heat-gated cation
channel/capsaicin receptor expressed by sensory neurons, has opened the door for …