The increase in the prevalence of obesity represents a worldwide phenomenon in all age
groups and is pathologically and genetically correlated with several metabolic and …

Leukocyte trafficking to the small and large intestines is tightly controlled to maintain
intestinal immune homeostasis, mediate immune responses, and regulate inflammation. A …

Crohn's disease (CD) and ulcerative colitis (UC), two forms of inflammatory bowel disease
(IBD), are chronic, relapsing, and tissue destructive lesions that are accompanied by the …

Chemokines, binding their various G protein-coupled receptors, lead the way for leukocytes
in health and inflammation. Yet chemokine receptor expression is not limited to leukocytes …

Background Aryl hydrocarbon receptor (AhR), a transcription factor of the bHLH/PAS family,
is well characterized to regulate the biochemical and toxic effects of environmental …

The activation and entry of antigen-specific CD8+ T cells into the central nervous system is
an essential step towards clearance of West Nile virus (WNV) from infected neurons. The …

The tumor microenvironment of human non-small cell lung cancer (NSCLC) is composed
largely of stromal cells, including fibroblasts, yet these cells have been the focus of few …

Inflammatory bowel disease is a chronic, relapsing, and tissue-destructive disease.
Resveratrol (3, 4, 5-trihydroxy-trans-stilbene), a naturally occurring polyphenol that exhibits …

CXCL10 was recently shown to exert antimalignancy functions by influencing the tumor
microenvironment. Here, we have taken a different approach, investigating the effects of …

Osteosarcoma is one of the most aggressive malignant bone tumors worldwide. Although
great advancements have been made in its treatment owing to the advent of neoadjuvant …