Skeletal muscle and bone share common embryological origins from mesodermal cell
populations and also display common growth trajectories early in life. Moreover, muscle and …

Long-term exposure to a diabetic environment leads to changes in bone metabolism and
impaired bone micro-architecture through a variety of mechanisms on molecular and …

Marrow adipose tissue (MAT) accumulates in diverse clinical conditions but remains poorly
understood. Here we show region-specific variation in MAT adipocyte development …

Bone marrow is one of the largest organs in the human body, enclosing adipocytes,
hematopoietic stem cells, which are responsible for blood cell production, and mesenchymal …

Marrow adipocytes, collectively termed marrow adipose tissue (MAT), reside in the bone
marrow in close contact to bone cells and haematopoietic cells. Marrow adipocytes arise …

The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide, especially as a
result of our aging society, high caloric intake and sedentary lifestyle. Besides the well …

Osteoporosis is a systemic skeletal disease with a high prevalence worldwide, characterized
by low bone mass and microarchitectural deterioration, predisposing an individual to fragility …

With growing interest in the connection between fat and bone, there has been increased
investigation of the relationship with marrow fat in particular. Clinical research has been …

Marrow adipose tissue (MAT) is a unique fat depot, located in the skeleton, that has the
potential to contribute to both local and systemic metabolic processes. In this review we …

Accumulating evidence supports a complex relationship between adiposity and
osteoporosis in overweight/obese individuals, with local interactions and endocrine …