Genomes are self-organized and self-maintained as long, complex macromolecules of
chromatin. The inherent heterogeneity, stochasticity, phase separation, and chromatin …

As a multifunctional DNA repair enzyme, human apurinic/apyrimidinic endonuclease 1
(APE1) plays a pivotal role in many cellular processes. In recent years, it has been …

Base excision repair (BER) is carried out by a series of proteins that function in a step-by-
step process to identify, remove, and replace DNA damage. During BER, the DNA …

Coordination of enzymatic activities in the course of base excision repair (BER) is essential
to ensure complete repair of damaged bases. Two major mechanisms underlying the …

The base excision repair (BER) pathway involves sequential action of DNA glycosylases
and apurinic/apyrimidinic (AP) endonucleases to incise damaged DNA and prepare DNA …

Base excision repair (BER) is a major cellular pathway for DNA damage repair. During BER,
DNA polymerase β (Polβ) is hypothesized to first perform gap-filling DNA synthesis by its …

The androgen receptor (AR) is an important drug target in prostate cancer and a driver of
castration-resistant prostate cancer (CRPC). A significant challenge in designing effective …

ABSTRACT Streptococcus pyogenes (Sp) Cas9 has been widely utilized to edit genomes
across diverse species. To achieve high efficiency and specificity as a gene editing enzyme …

Applying sunscreen on human skin provides photoprotection against the harmful ultraviolet
(UV) radiation of the sun. Sunscreen absorbs UV radiations and dissipates the absorbed …

Hydroxydeoxyguanosine (8-OHdG) is well known not only as an effective biomarker of
oxidative stress but also as a mutagenic DNA modification. Incorporation of dAMP at the …