Development of Next Generation Streptococcus pneumoniae Vaccines Conferring Broad Protection
Streptococcus pneumoniae is a major pathogen causing pneumonia with over 2 million
deaths annually, especially in young children and the elderly. To date, at least 98 different …
deaths annually, especially in young children and the elderly. To date, at least 98 different …
[HTML][HTML] The epidemiology of febrile illness in sub-Saharan Africa: implications for diagnosis and management
Background Fever is among the most common symptoms of people living in Africa, and
clinicians are challenged by the similar clinical features of a wide spectrum of potential …
clinicians are challenged by the similar clinical features of a wide spectrum of potential …
Safety, tolerability, and immunogenicity of a 20-valent pneumococcal conjugate vaccine (PCV20) in adults 60 to 64 years of age
D Hurley, C Griffin, M Young Jr, DA Scott… - Clinical Infectious …, 2021 - academic.oup.com
Abstract Background Pneumococcal conjugate vaccines (PCVs) have significantly
decreased pneumococcal disease worldwide; however, expanding serotype coverage may …
decreased pneumococcal disease worldwide; however, expanding serotype coverage may …
Pneumococcal lineages associated with serotype replacement and antibiotic resistance in childhood invasive pneumococcal disease in the post-PCV13 era: an …
Background Invasive pneumococcal disease remains an important health priority owing to
increasing disease incidence caused by pneumococci expressing non-vaccine serotypes …
increasing disease incidence caused by pneumococci expressing non-vaccine serotypes …
Divergent serotype replacement trends and increasing diversity in pneumococcal disease in high income settings reduce the benefit of expanding vaccine valency
Streptococcus pneumoniae is a significant cause of otitis media, pneumonia, and meningitis.
Only seven of the approximately 100 serotypes were initially included in the pneumococcal …
Only seven of the approximately 100 serotypes were initially included in the pneumococcal …
Nationwide trends of invasive pneumococcal disease in Spain from 2009 through 2019 in children and adults during the pneumococcal conjugate vaccine era
S de Miguel, M Domenech… - Clinical Infectious …, 2021 - academic.oup.com
Background Introduction of pneumococcal conjugate vaccines (PCVs) has reduced the
disease caused by vaccine serotypes in children, providing herd protection to adults …
disease caused by vaccine serotypes in children, providing herd protection to adults …
A trial to evaluate the safety and immunogenicity of a 20-valent pneumococcal conjugate vaccine in populations of adults≥ 65 years of age with different prior …
K Cannon, C Elder, M Young, DA Scott, IL Scully… - Vaccine, 2021 - Elsevier
Introduction A 20-valent pneumococcal conjugate vaccine, PCV20, was developed to
expand protection against vaccine-preventable pneumococcal disease. PCV20 contains the …
expand protection against vaccine-preventable pneumococcal disease. PCV20 contains the …
The metabolic, virulence and antimicrobial resistance profiles of colonising Streptococcus pneumoniae shift after PCV13 introduction in urban Malawi
Streptococcus pneumoniae causes substantial mortality among children under 5-years-old
worldwide. Polysaccharide conjugate vaccines (PCVs) are highly effective at reducing …
worldwide. Polysaccharide conjugate vaccines (PCVs) are highly effective at reducing …
[HTML][HTML] A phase 3, randomized, double-blind study to evaluate the immunogenicity and safety of 3 lots of 20-valent pneumococcal conjugate vaccine in …
NP Klein, P Peyrani, K Yacisin, N Caldwell, X Xu… - Vaccine, 2021 - Elsevier
Introduction Introduction of pneumococcal conjugate vaccines (PCVs), including the 13-
valent PCV (PCV13), has considerably reduced pneumococcal disease burden. However …
valent PCV (PCV13), has considerably reduced pneumococcal disease burden. However …
Airway Prevotella promote TLR2-dependent neutrophil activation and rapid clearance of Streptococcus pneumoniae from the lung
KJ Horn, MA Schopper, ZG Drigot, SE Clark - Nature Communications, 2022 - nature.com
This study investigates how specific members of the lung microbiome influence the early
immune response to infection. Prevotella species are a major component of the endogenous …
immune response to infection. Prevotella species are a major component of the endogenous …