Synthetic circRNA therapeutics: innovations, strategies, and future horizons

J Cai, Z Qiu, W Chi‐Shing Cho, Z Liu, S Chen, H Li… - MedComm, 2024 - Wiley Online Library
Small molecule drugs are increasingly emerging as innovative and effective treatments for
various diseases, with mRNA therapeutics being a notable representative. The success of …

[HTML][HTML] Roles of M1 Macrophages and Their Extracellular Vesicles in Cancer Therapy

W Zhou, F Yang, X Zhang - Cells, 2024 - mdpi.com
Tumor-associated macrophages (TAMs) are inflammatory cells that are important
components of the tumor microenvironment. TAMs are functionally heterogeneous and …

Dietary probiotic-derived extracellular vesicles as delivery systems of bioactive compounds to maintain intestinal homeostasis

K Wang, X Li, K Huang, H Wu, M Tan, W Su - Chemical Engineering …, 2025 - Elsevier
Gut homeostasis is crucial in defending against pathogens and maintaining microbial
balance. Changes in modern lifestyle, such as poor dietary habits and lack of exercise, have …

Discovering the role of microRNAs and exosomal microRNAs in chest and pulmonary diseases: a spotlight on chronic obstructive pulmonary disease

FY Nan, B Liu, C Yao - Molecular Genetics and Genomics, 2024 - Springer
Chronic obstructive pulmonary disease (COPD) is a progressive respiratory condition and
ranks as the fourth leading cause of mortality worldwide. Despite extensive research efforts …

Unleashing the potential of mRNA: Overcoming delivery challenges with nanoparticles

Q Chen, KG Huo, SM Ji, SD Pang… - Bioengineering & …, 2024 - Wiley Online Library
Messenger RNA (mRNA) has emerged as a promising therapeutic strategy for various
diseases, including cancer, infectious diseases, and genetic disorders. The mRNA‐based …

[HTML][HTML] Nanoparticle Strategies for Treating CNS Disorders: A Comprehensive Review of Drug Delivery and Theranostic Applications

C Toader, AV Dumitru, L Eva, M Serban… - International Journal of …, 2024 - mdpi.com
This review aims to address the significant challenges of treating central nervous system
(CNS) disorders such as neurodegenerative diseases, strokes, spinal cord injuries, and …

Advances in the treatment of liver injury based on mesenchymal stem cell-derived exosomes

C Hu, L Wang - Stem Cell Research & Therapy, 2024 - Springer
Mesenchymal stem cells (MSCs) have shown a great potential role in treating liver injury.
MSCs can promote liver regeneration by differentiating into hepatocytes, and can also …

Exosome: an overview on enhanced biogenesis by small molecules

A Bavafa, M Izadpanahi, E Hosseini… - Naunyn-Schmiedeberg's …, 2025 - Springer
Exosomes are extracellular vesicles that received attention for their potential use in the
treatment of various injuries. They communicate intercellularly by transferring genetic and …

[HTML][HTML] Extracellular vesicle-based drug delivery systems in cancer

R Huang, J Zhu, R Fan, Y Tang, L Hu, HJ Lee… - Extracellular …, 2024 - Elsevier
Extracellular vesicles are lipid bilayer-enclosed extracellular membrane vesicles secreted
from cells that have gradually shown promise in cancer treatment. As an essential …

[PDF][PDF] Progenitor Cells, Microglia, and Non-coding RNAs: Orchestrators of Glioblastoma Pathogenesis and Therapeutic Resistance

A Husain, F Ahmad, S Pandey, TK Upadhyay, S Kang… - 2024 - preprints.org
Glioblastoma (GB) remains a major challenge owing to its extremely aggressive nature and
resistance to conventional therapies. This review focuses on the intricate roles of progenitor …