Drug resistance in tuberculosis (TB) is a particular problem because the lengthy therapy of
at least 6 months makes patient compliance very difficult, which frequently creates drug …

Fluoroquinolone resistance in Mycobacterium tuberculosis has become increasingly
important. A review of mutations in DNA gyrase, the fluoroquinolone target, is needed to …

Page 1 Catalogue of mutations in Mycobacterium tuberculosis complex and their
association with drug resistance Second edition Page 2 Page 3 Catalogue of mutations in …

The antimicrobial resistance crisis requires the introduction of novel antibiotics. The use of
conventional broad-spectrum compounds selects for resistance in off-target pathogens and …

Background Extensively drug-resistant tuberculosis has been reported in 45 countries,
including countries with limited resources and a high burden of tuberculosis. We describe …

The GenoType MTBDR sl test rapidly detects resistance to ethambutol, fluoroquinolones,
and second-line aminoglycosides (amikacin and kanamycin) and cyclic peptide …

Mycobacterium tuberculosis DNA gyrase, an indispensable nanomachine involved in the
regulation of DNA topology, is the only type II topoisomerase present in this organism and is …

The enormous genetic flexibility of bacteria jeopardizes the usefulness of currently available
antibiotics, and requires new approaches to antibiotic discovery and development …

Bacterial DNA gyrase is an important target of antibacterial agents, including
fluoroquinolones. In most bacterial species, fluoroquinolones inhibit DNA gyrase and …

The treatment of drug-resistant tuberculosis cases is challenging, as drug options are
limited, and the existing diagnostics are inadequate. Whole-genome sequencing (WGS) has …