The use of antibody-drug conjugates (ADCs) as a therapeutic platform to treat cancer has
recently gained substantial momentum. This therapeutic modality has the potential to …

Traditionally, signal transduction from GPCRs is thought to emanate from the cell surface
where receptor interactions with external stimuli can be transformed into a broad range of …

The plethora of functions of glutamate in the brain are mediated by the complementary
actions of ionotropic and metabotropic glutamate receptors (mGluRs). The ionotropic …

Glucose-dependent insulinotropic polypeptide (GIP), an incretin hormone secreted from
gastrointestinal K cells in response to food intake, has an important role in the control of …

The trillions of synaptic connections within the human brain are shaped by experience and
neuronal activity, both of which underlie synaptic plasticity and ultimately learning and …

Rationale Effective pharmacological treatments to prevent cocaine relapse remain elusive.
In male rats, ceftriaxone attenuates the reinstatement of cocaine-seeking while increasing …

The metabotropic glutamate receptors (mGlu receptors) are G protein-coupled receptors that
bind to the excitatory neurotransmitter glutamate and are important in the modulation of …

Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors (GPCRs) that
are activated by the neurotransmitter glutamate in the central nervous system. Among the …

Norbin (Neurochondrin, NCDN) is a highly conserved 79 kDa adaptor protein that was first
identified more than a quarter of a century ago as a gene up-regulated in rat hippocampus …

Group I mGluRs have diverse functions in some fundamental neuronal processes, including
modulation of synaptic plasticity; and dysregulation of these receptors could lead to various …