Associations among dietary omega‐3 polyunsaturated fatty acids, the gut microbiota, and intestinal immunity

Y Fu, Y Wang, H Gao, DH Li, RR Jiang… - Mediators of …, 2021 - Wiley Online Library
Omega‐3 polyunsaturated fatty acids (omega‐3 PUFAs), which are essential fatty acids that
humans should obtain from diet, have potential benefits for human health. In addition to …

Omega-3 fatty acids and neurodegenerative diseases: new evidence in clinical trials

R Avallone, G Vitale, M Bertolotti - International journal of molecular …, 2019 - mdpi.com
A nutritional approach could be a promising strategy to prevent or slow the progression of
neurodegenerative diseases such as Parkinson's and Alzheimer's disease, since there is no …

[HTML][HTML] Exercise immunology: future directions

DC Nieman, BD Pence - Journal of Sport and Health Science, 2020 - Elsevier
Several decades of research in the area of exercise immunology have shown that the
immune system is highly responsive to acute and chronic exercise training. Moderate …

sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury

CB Bergmann, CB McReynolds… - Proceedings of the …, 2022 - National Acad Sciences
Fatty acid composition in the Western diet has shifted from saturated to polyunsaturated fatty
acids (PUFAs), and specifically to linoleic acid (LA, 18: 2), which has gradually increased in …

Emerging mechanisms of obesity-associated immune dysfunction

SR Shaikh, MA Beck, Y Alwarawrah… - Nature Reviews …, 2024 - nature.com
Obesity is associated with a wide range of complications, including type 2 diabetes mellitus,
cardiovascular disease, hypertension and nonalcoholic fatty liver disease. Obesity also …

Biological role of unsaturated fatty acid desaturases in health and disease

A Czumaj, T Śledziński - Nutrients, 2020 - mdpi.com
Polyunsaturated fatty acids (PUFAs) are considered one of the most important components
of cells that influence normal development and function of many organisms, both eukaryotes …

Targeting NRF2–KEAP1 axis by Omega-3 fatty acids and their derivatives: Emerging opportunities against aging and diseases

S Davinelli, A Medoro, M Intrieri, L Saso… - Free Radical Biology …, 2022 - Elsevier
The transcription factor NRF2 and its endogenous inhibitor KEAP1 play a crucial role in the
maintenance of cellular redox homeostasis by regulating the gene expression of diverse …

Omega-3 polyunsaturated fatty acids and the intestinal epithelium—a review

LA Durkin, CE Childs, PC Calder - Foods, 2021 - mdpi.com
Epithelial cells (enterocytes) form part of the intestinal barrier, the largest human interface
between the internal and external environments, and responsible for maintaining regulated …

[HTML][HTML] Using comprehensive lipid profiling to study effects of PFHxS during different stages of early zebrafish development

M Xu, J Legradi, P Leonards - Science of the Total Environment, 2022 - Elsevier
PFHxS (Perfluorohexane sulfonic acid) is one of the short-chain perfluoroalkyl substances
(PFASs) which are widely used in many industrial and consumer applications. However …

Modulating tumor-associated macrophage polarization by synthetic and natural PPARγ ligands as a potential target in breast cancer

G Gionfriddo, P Plastina, G Augimeri, S Catalano… - Cells, 2020 - mdpi.com
Activation of peroxisome proliferator-activated receptor gamma (PPARγ) elicits anti-
proliferative effects on different tumor cells, including those derived from breast cancer …