Liquid‐assisted grinding mechanochemistry in the synthesis of pharmaceuticals

P Ying, J Yu, W Su - Advanced Synthesis & Catalysis, 2021 - Wiley Online Library
Mechanochemical reactions by milling, grinding or other types of mechanical action have
emerged as a salient green approach because of its wide applications towards academic …

Metal–organic framework composites from a mechanochemical process

W Wang, M Chai, MYB Zulkifli, K Xu, Y Chen… - … Systems Design & …, 2023 - pubs.rsc.org
Metal–organic frameworks (MOFs) consist of metal ions or clusters coordinated with organic
ligands such as imidazolate or carboxylate ligands. Owing to the high porosity and surface …

A decade of advances in the reaction of nitrogen sources and alkynes for the synthesis of triazoles

JSS Neto, G Zeni - Coordination Chemistry Reviews, 2020 - Elsevier
The cyclization reactions of alkynes have become one of the most important and useful
methodologies for the preparation of heterocycles. To this end, the association between …

[HTML][HTML] Ball Milling Promoted N-Heterocycles Synthesis

TH El-Sayed, A Aboelnaga, MA El-Atawy, M Hagar - Molecules, 2018 - mdpi.com
In the last years, numerous protocols have been published using ball milling for organic
synthesis. Compared to other methods such as microwave or ultrasound irradiation and …

Diastereoselective synthesis of dispiro [indoline-3, 3′-furan-2′, 3′′-pyrrolidine] via [3+ 2] cycloaddition reaction of MBH maleimides of isatins and 1, 3-dicarbonyl …

LN Pan, J Sun, RG Shi, CG Yan - Organic Chemistry Frontiers, 2020 - pubs.rsc.org
In the presence of mixed bases DABCO and K2CO3, the reaction of MBH maleimides of
isatins with various cyclic 1, 3-dicarbonyl compounds such as 1, 3-cyclohexanedione …

Solvent-free N-iodosuccinimide-promoted synthesis of spiroimidazolines from alkenes and amidines under ball-milling conditions

H Xu, K Chen, HW Liu, GW Wang - Organic Chemistry Frontiers, 2018 - pubs.rsc.org
A novel N-iodosuccinimide-promoted intermolecular cyclization between alkenes and
amidines has been demonstrated under solvent-free ball-milling conditions, affording a …

Practical Coprecipitation Approach for High-Aspect Ratio Cupric Oxide Nanoparticles: A Sustainable Catalytic Platform for Huisgen and Fluorogenic Click Chemistry

S Sampath, M Vadivelu, AA Raheem… - Industrial & …, 2022 - ACS Publications
Herein, we disclose a practical coprecipitation method, which grants access to cupric oxide
nanoparticles in high aspect ratio together with comprehensive characterization (X-ray …

Mechanochemical access to functional clickates with nitro-retentive selectivity via organocatalyzed oxidative azide-olefin cycloaddition

M Vadivelu, AA Raheem, JP Raj, J Elangovan… - Organic …, 2022 - ACS Publications
4-Nitro-1, 2, 3-triazoles are crucial precursors for high energy materials, and their practical
synthesis is a long-standing problem. Herein, we communicate a mechanochemical route …

Harnessing the TEMPO-catalyzed aerobic oxidation for Machetti–De Sarlo reaction toward sustainable synthesis of isoxazole libraries

M Vadivelu, S Sampath, K Muthu… - The Journal of …, 2019 - ACS Publications
A practical synthesis of isoxazole/isoxazoline derivatives via Machetti–De Sarlo reaction
under sustainable conditions has been accomplished. This protocol involves the use of …

Ultrasound-assisted catalyst free synthesis of 1, 4-/1, 5-disubstituted-1, 2, 3-triazoles in aqueous medium

T Kiranmye, M Vadivelu, S Sampath, K Muthu… - Sustainable Chemistry …, 2021 - Elsevier
A convenient and straight forward strategy for the synthesis of 1-substituted-4-acyl-1, 2, 3-
triazoles and 1, 5-disubstituted-1, 2, 3-triazoles via eliminative [3+ 2] cycloaddition of azides …